Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00938
Entry Name
UniProt Accession
Theoretical PI
6.33
Molecular Weight
21655.83
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
GTPase KRas, N-terminally processed
Protein Synonyms/Alias
K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras;
Gene Name
KRAS
Gene Synonyms/Alias
KRAS2; RASK2;
Created Date
21-JUL-1986
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
186
Canonical
GCVKIKKCIIM****
[1]
S-Farnesylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Rowell CA, Kowalczyk JJ, Lewis MD, Garcia AM. Direct demonstration ofgeranylgeranylation and farnesylation of Ki-Ras in vivo. J Biol Chem. 1997 May30;272(22):14093-7.[PMID:9162034]
Functional Description
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Sequence Annotation
Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Region: 166 185 Hypervariable region.
Motif: 32 40 Effector region.
Modified residue: 1 1 N-acetylmethionine; in GTPase KRas;alternate.
Modified residue: 2 2 N-acetylthreonine; in GTPase KRas, N-terminally processed.
Modified residue: 104 104 N6-acetyllysine.
Modified residue: 186 186 Cysteine methyl ester.
Protein Length
189 AA.
Protein Sequence
(Canonical)
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG  60
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL  120
PSRTVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC  180
VKIKKCIIM                                                          189
FASTA
(Canonical)
>LipidDB-9606-00938|P01116
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
Gene Ontology
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0019003; F:GDP binding; IEA:Ensembl
GO:0019002; F:GMP binding; IEA:Ensembl
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0032403; F:protein complex binding; IDA:MGI
GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl
GO:0000186; P:activation of MAPKK activity; TAS:Reactome
GO:0007411; P:axon guidance; TAS:Reactome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome
GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0045087; P:innate immune response; TAS:Reactome
GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome
GO:0050900; P:leukocyte migration; TAS:Reactome
GO:0000165; P:MAPK cascade; TAS:Reactome
GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl
GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0010628; P:positive regulation of gene expression; IMP:BHF-UCL
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl
GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Ensembl
GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL
GO:0035022; P:positive regulation of Rac protein signal transduction; IEA:Ensembl
GO:0007265; P:Ras protein signal transduction; TAS:Reactome
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl
GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl
GO:0051384; P:response to glucocorticoid; IEA:Ensembl
GO:0051385; P:response to mineralocorticoid; IEA:Ensembl
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome
GO:0035176; P:social behavior; IEA:Ensembl
GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl
GO:0008542; P:visual learning; IEA:Ensembl
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00173; RAS;
PROSITE
PROSITE; PS51421; RAS;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;