| Tag |
Content |
LipidDB ID |
LipidDB-9606-00935 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
6.48 |
Molecular Weight |
43691.82 |
Genbank Protein ID |
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Genbank Nucleotide ID |
|
Protein Name |
Regulator of G-protein signaling 20 |
Protein Synonyms/Alias |
RGS20; Gz-selective GTPase-activating protein; G(z)GAP; Gz-GAP; Regulator of G-protein signaling Z1; Regulator of Gz-selective protein signaling 1; |
Gene Name |
RGS20 |
Gene Synonyms/Alias |
RGSZ1; ZGAP1; |
Created Date |
20-JUN-2001 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
11 | Canonical | LSQDNQECLQKHFSR | [1] | S-Palmitoylation | 209 | Canonical | SRGSNACCFCWCCCC | [1] | S-Palmitoylation | 211 | Canonical | GSNACCFCWCCCCSC | [1] | S-Palmitoylation | 213 | Canonical | NACCFCWCCCCSCSC | [1] | S-Palmitoylation | 214 | Canonical | ACCFCWCCCCSCSCL | [1] | S-Palmitoylation | 215 | Canonical | CCFCWCCCCSCSCLT | [1] | S-Palmitoylation | 216 | Canonical | CFCWCCCCSCSCLTV | [1] | S-Palmitoylation | 218 | Canonical | CWCCCCSCSCLTVRN | [1] | S-Palmitoylation | 220 | Canonical | CCCCSCSCLTVRNQE | [1] | S-Palmitoylation | 295 | Canonical | NMLFWMACEELKKEA | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). |
Sequence Annotation |
Domain: 262 378 RGS.
|
Protein Length |
388 AA. |
Protein Sequence
(Canonical) |
MPQLSQDNQE CLQKHFSRPS IWTQFLPLFR AQRYNTDIHQ ITENEGDLRA VPDIKSFPPA 60
QLPDSPAAPK LFGLLSSPLS SLARFFSHLL RRPPPEAPRR RLDFSPLLPA LPAARLSRGH 120
EELPGRLSLL LGAALALPGR PSGGRPLRPP HPVAKPREED ATAGQSSPMP QMGSERMEMR 180
KRQMPAAQDT PGAAPGQPGA GSRGSNACCF CWCCCCSCSC LTVRNQEDQR PTIASHELRA 240
DLPTWEESPA PTLEEVNAWA QSFDKLMVTP AGRNAFREFL RTEFSEENML FWMACEELKK 300
EANKNIIEEK ARIIYEDYIS ILSPKEVSLD SRVREVINRN MVEPSQHIFD DAQLQIYTLM 360
HRDSYPRFMN SAVYKDLLQS LSEKSIEA 388
|
FASTA
(Canonical) |
>LipidDB-9606-00935|O76081
MPQLSQDNQECLQKHFSRPSIWTQFLPLFRAQRYNTDIHQITENEGDLRAVPDIKSFPPA
QLPDSPAAPKLFGLLSSPLSSLARFFSHLLRRPPPEAPRRRLDFSPLLPALPAARLSRGH
EELPGRLSLLLGAALALPGRPSGGRPLRPPHPVAKPREEDATAGQSSPMPQMGSERMEMR
KRQMPAAQDTPGAAPGQPGAGSRGSNACCFCWCCCCSCSCLTVRNQEDQRPTIASHELRA
DLPTWEESPAPTLEEVNAWAQSFDKLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKK
EANKNIIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMVEPSQHIFDDAQLQIYTLM
HRDSYPRFMNSAVYKDLLQSLSEKSIEA
|
Gene Ontology |
GO:0005737; C:cytoplasm; IBA:RefGenome GO:0005634; C:nucleus; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; IBA:RefGenome GO:0005096; F:GTPase activator activity; IBA:RefGenome GO:0043547; P:positive regulation of GTPase activity; IBA:GOC GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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