LipidDB-9606-00927

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00927

Entry Name

UniProt Accession

Q08289; A6PVM5; A6PVM7; A6PVM8; O00304; Q5QJ99; Q5QJA0; Q5VVG9; Q5VVH0; Q5VWV6; Q6TME1; Q6TME2; Q6TME3; Q8WX81; Q96NZ3; Q96NZ4; Q96NZ5; Q9BWU2; Q9HD32; Q9Y340; Q9Y341;

Theoretical PI

8.11

Molecular Weight

73580.62

Genbank Protein ID

AAB51370.1; AAB53332.1; AAL16948.1; AAL16949.1; AAL16950.1; AAL16951.1; AAG01473.2; AAQ97606.1; AAQ97607.1; AAQ97608.1; AAQ97609.1; AAQ97610.1; AAD33729.1; AAD33730.1; AAK16994.1; AAK16994.1; AAK16994.1; AAK16994.1; AAK16994.1; AAK16994.1; AAL73495.1; CAH70125.1; CAH70125.1; CAH70125.1; CAH70125.1; CAH71352.1; CAH71352.1; CAH71352.1; CAH71352.1; CAH73209.1; CAH73209.1; CAH73209.1; CAH73209.1; CAI14734.1; CAI14734.1; CAI14734.1; CAI14734.1; CAH70065.1; CAH70065.1; CAH70065.1; CAH70065.1; CAH70066.1; CAH70066.1; CAH70066.1; CAH70066.1; CAH70126.1; CAH70126.1; CAH70126.1; CAH70126.1; CAH71350.1; CAH71350.1; CAH71350.1; CAH71350.1; CAH71351.1; CAH71351.1; CAH71351.1; CAH71351.1; CAH71353.1; CAH71353.1; CAH71353.1; CAH71353.1; CAH73207.1; CAH73207.1; CAH73207.1; CAH73207.1; CAH73208.1; CAH73208.1; CAH73208.1; CAH73208.1; CAH73210.1; CAH73210.1; CAH73210.1; CAH73210.1; CAI14732.1; CAI14732.1; CAI14732.1; CAI14732.1; CAI14733.1; CAI14733.1; CAI14733.1; CAI14733.1; CAI14735.1; CAI14735.1; CAI14735.1; CAI14735.1; CAO03475.1; CAO03475.1; CAO03475.1; CAO03475.1; CAO03513.1; CAO03513.1; CAO03513.1; CAO03513.1; CAO03515.1; CAO03515.1; CAO03515.1; CAO03515.1; CAO03516.1; CAO03516.1; CAO03516.1; CAO03516.1; CAO03603.1; CAO03603.1; CAO03603.1; CAO03603.1; CAO03605.1; CAO03605.1; CAO03605.1; CAO03605.1; CAO03606.1; CAO03606.1; CAO03606.1; CAO03606.1; CAO03634.1; CAO03634.1; CAO03634.1; CAO03634.1; CAO03636.1; CAO03636.1; CAO03636.1; CAO03636.1; CAO03637.1; CAO03637.1; CAO03637.1; CAO03637.1; CAO03672.1; CAO03672.1; CAO03672.1; CAO03672.1; CAO03674.1; CAO03674.1; CAO03674.1; CAO03674.1; EAW86196.1; EAW86197.1; AAI36410.1;

Genbank Nucleotide ID

Protein Name

Voltage-dependent L-type calcium channel subunit beta-2

Protein Synonyms/Alias

CAB2; Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB;

Gene Name

CACNB2

Gene Synonyms/Alias

CACNLB2; MYSB;

Created Date

01-OCT-1994

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
3	Isoform 2	*****MQCCGLVHRR	[1]	S-Palmitoylation
4	Isoform 2	****MQCCGLVHRRR	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Chien AJ, Carr KM, Shirokov RE, Rios E, Hosey MM. Identification ofpalmitoylation sites within the L-type calcium channel beta2a subunit and effectson channel function. J Biol Chem. 1996 Oct 25;271(43):26465-8.[PMID:8900112]

Functional Description

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Sequence Annotation

Domain: 114 183 SH3.
Functional site: 549 549 Required for CaMK2D-binding.
Modified residue: 554 554 Phosphothreonine; by CaMK2D.

Protein Length

660 AA.

Protein Sequence
(Isoform 2)

MQCCGLVHRR RVRVSYGSAD SYTSRPSDSD VSLEEDREAV RREAERQAQA QLEKAKTKPV  60
AFAVRTNVSY SAAHEDDVPV PGMAISFEAK DFLHVKEKFN NDWWIGRLVK EGCEIGFIPS  120
PVKLENMRLQ HEQRAKQGKF YSSKSGGNSS SSLGDIVPSS RKSTPPSSAI DIDATGLDAE  180
ENDIPANHRS PKPSANSVTS PHSKEKRMPF FKKTEHTPPY DVVPSMRPVV LVGPSLKGYE  240
VTDMMQKALF DFLKHRFEGR ISITRVTADI SLAKRSVLNN PSKHAIIERS NTRSSLAEVQ  300
SEIERIFELA RTLQLVVLDA DTINHPAQLS KTSLAPIIVY VKISSPKVLQ RLIKSRGKSQ  360
AKHLNVQMVA ADKLAQCPPE LFDVILDENQ LEDACEHLAD YLEAYWKATH PPSSSLPNPL  420
LSRTLATSSL PLSPTLASNS QGSQGDQRTD RSAPIRSASQ AEEEPSVEPV KKSQHRSSSS  480
APHHNHRSGT SRGLSRQETF DSETQESRDS AYVEPKEDYS HDHVDHYASH RDHNHRDETH  540
GSSDHRHRES RHRSRDVDRE QDHNECNKQR SRHKSKDRYC EKDGEVISKK RNEAGEWNRD  600
VYIRQ                                                              605

FASTA
(Isoform 2)

>LipidDB-9606-00927|Q08289-2
MQCCGLVHRRRVRVSYGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPV
AFAVRTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPS
PVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAE
ENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYE
VTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQ
SEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQ
AKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLPNPL
LSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRSSSS
APHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRDETH
GSSDHRHRESRHRSRDVDREQDHNECNKQRSRHKSKDRYCEKDGEVISKKRNEAGEWNRD
VYIRQ

Gene Ontology

GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB
GO:0005891; C:voltage-gated calcium channel complex; IDA:BHF-UCL
GO:0005262; F:calcium channel activity; NAS:UniProtKB
GO:0005245; F:voltage-gated calcium channel activity; IDA:BHF-UCL
GO:0007411; P:axon guidance; TAS:Reactome
GO:0070509; P:calcium ion import; IDA:BHF-UCL
GO:0007528; P:neuromuscular junction development; TAS:ProtInc
GO:0051928; P:positive regulation of calcium ion transport; IDA:BHF-UCL
GO:0007268; P:synaptic transmission; IEA:Ensembl
GO:0006810; P:transport; TAS:ProtInc
GO:0007601; P:visual perception; IEA:Ensembl

Interpro

InterPro; IPR008145; GK/Ca_channel_bsu
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR001452; SH3_domain
InterPro; IPR005444; VDCC_L_b2su
InterPro; IPR000584; VDCC_L_bsu

Pfam

Pfam; PF00625; Guanylate_kin;
Pfam; PF12052; VGCC_beta4Aa_N;

SMART

SMART; SM00072; GuKc;
SMART; SM00326; SH3;

PROSITE

PROSITE; PS50002; SH3;

PRINTS

PRINTS; PR01626; LCACHANNELB;
PRINTS; PR01628; LCACHANNELB2;