LipidDB ID

LipidDB-9606-00905

Entry Name

UniProt Accession

Q99497; B2R4Z1; O14805; Q6DR95; Q7LFU2;

Theoretical PI

6.32

Molecular Weight

19891.05

Genbank Protein ID

BAA09603.2; AAC12806.1; BAB71782.1; BAG34938.1; CAB52550.1; EAW71591.1; AAH08188.1; AAT68961.1;

Genbank Nucleotide ID

D61380; AF021819; AB073864; AK312000; AL034417; CH471130; BC008188; AB045294; AY648999;

Protein Name

Protein DJ-1

Protein Synonyms/Alias

3.4.-.-; Oncogene DJ1; Parkinson disease protein 7;

Gene Name

PARK7

Gene Synonyms/Alias

Created Date

07-DEC-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Kim KS, Kim JS, Park JY, Suh YH, Jou I, Joe EH, Park SM. DJ-1 associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes. Hum Mol Genet. 2013 Dec 1;22(23):4805-17. doi: 10.1093/hmg/ddt332.Epub 2013 Jul 11.[PMID:23847046]

Functional Description

Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.

Sequence Annotation

Active site: 106 106
Active site: 126 126
Modified residue: 67 67 Phosphotyrosine.
Modified residue: 106 106 Cysteine sulfinic acid (-SO2H);alternate.
Modified residue: 148 148 N6-acetyllysine.
Modified residue: 182 182 N6-succinyllysine.

Protein Length

189 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0000785; C:chromatin; IDA:ParkinsonsUK-UCL
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005829; C:cytosol; IMP:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005739; C:mitochondrion; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0016605; C:PML body; IDA:ParkinsonsUK-UCL
GO:0050681; F:androgen receptor binding; IPI:ParkinsonsUK-UCL
GO:1903135; F:cupric ion binding; IDA:ParkinsonsUK-UCL
GO:1903136; F:cuprous ion binding; IDA:ParkinsonsUK-UCL
GO:0019955; F:cytokine binding; IPI:ParkinsonsUK-UCL
GO:0019899; F:enzyme binding; IPI:ParkinsonsUK-UCL
GO:1990422; F:glyoxalase (glycolic acid-forming) activity; IDA:ParkinsonsUK-UCL
GO:0019172; F:glyoxalase III activity; IDA:ParkinsonsUK-UCL
GO:0042802; F:identical protein binding; IPI:ParkinsonsUK-UCL
GO:0036478; F:L-dopa decarboxylase activator activity; IDA:ParkinsonsUK-UCL
GO:0003729; F:mRNA binding; IDA:UniProtKB
GO:0016684; F:oxidoreductase activity, acting on peroxide as acceptor; IDA:ParkinsonsUK-UCL
GO:0008233; F:peptidase activity; IDA:UniProtKB
GO:0004601; F:peroxidase activity; IEA:Ensembl
GO:0051920; F:peroxiredoxin activity; IEA:Ensembl
GO:0042803; F:protein homodimerization activity; IDA:UniProtKB
GO:0005102; F:receptor binding; IPI:UniProtKB
GO:0070491; F:repressing transcription factor binding; IPI:ParkinsonsUK-UCL
GO:0003723; F:RNA binding; TAS:ParkinsonsUK-UCL
GO:0097110; F:scaffold protein binding; IPI:ParkinsonsUK-UCL
GO:0044388; F:small protein activating enzyme binding; IPI:ParkinsonsUK-UCL
GO:0044390; F:small protein conjugating enzyme binding; IPI:ParkinsonsUK-UCL
GO:0016532; F:superoxide dismutase copper chaperone activity; IDA:ParkinsonsUK-UCL
GO:0003713; F:transcription coactivator activity; IGI:ParkinsonsUK-UCL
GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL
GO:0036470; F:tyrosine 3-monooxygenase activator activity; IDA:ParkinsonsUK-UCL
GO:1990381; F:ubiquitin-specific protease binding; IPI:ParkinsonsUK-UCL
GO:0008344; P:adult locomotory behavior; IEA:Ensembl
GO:0006914; P:autophagy; IEA:UniProtKB-KW
GO:0036471; P:cellular response to glyoxal; IDA:ParkinsonsUK-UCL
GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB
GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL
GO:0051583; P:dopamine uptake involved in synaptic transmission; IEA:Ensembl
GO:0046295; P:glycolate biosynthetic process; IDA:ParkinsonsUK-UCL
GO:1903190; P:glyoxal catabolic process; IDA:ParkinsonsUK-UCL
GO:0042743; P:hydrogen peroxide metabolic process; IDA:ParkinsonsUK-UCL
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW
GO:0019249; P:lactate biosynthetic process; IDA:GOC
GO:0051899; P:membrane depolarization; IEA:Ensembl
GO:0060081; P:membrane hyperpolarization; IEA:Ensembl
GO:0019243; P:methylglyoxal catabolic process to D-lactate; IDA:ParkinsonsUK-UCL
GO:0007005; P:mitochondrion organization; ISS:UniProtKB
GO:0043066; P:negative regulation of apoptotic process; IDA:ParkinsonsUK-UCL
GO:0060548; P:negative regulation of cell death; IDA:UniProtKB
GO:2001268; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; IMP:ParkinsonsUK-UCL
GO:1903073; P:negative regulation of death-inducing signaling complex assembly; IC:ParkinsonsUK-UCL
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB
GO:0010629; P:negative regulation of gene expression; IDA:ParkinsonsUK-UCL
GO:1903206; P:negative regulation of hydrogen peroxide-induced cell death; IMP:ParkinsonsUK-UCL
GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IDA:ParkinsonsUK-UCL
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL
GO:1901215; P:negative regulation of neuron death; IDA:ParkinsonsUK-UCL
GO:1903202; P:negative regulation of oxidative stress-induced cell death; IDA:ParkinsonsUK-UCL
GO:1903377; P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; IDA:ParkinsonsUK-UCL
GO:1901984; P:negative regulation of protein acetylation; IDA:ParkinsonsUK-UCL
GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB
GO:0046826; P:negative regulation of protein export from nucleus; IGI:ParkinsonsUK-UCL
GO:1903094; P:negative regulation of protein K48-linked deubiquitination; IDA:ParkinsonsUK-UCL
GO:0006469; P:negative regulation of protein kinase activity; IGI:ParkinsonsUK-UCL
GO:0001933; P:negative regulation of protein phosphorylation; IGI:ParkinsonsUK-UCL
GO:0033234; P:negative regulation of protein sumoylation; IDA:ParkinsonsUK-UCL
GO:0031397; P:negative regulation of protein ubiquitination; IDA:ParkinsonsUK-UCL
GO:1903122; P:negative regulation of TRAIL-activated apoptotic signaling pathway; IMP:ParkinsonsUK-UCL
GO:0051444; P:negative regulation of ubiquitin-protein transferase activity; IDA:ParkinsonsUK-UCL
GO:2000157; P:negative regulation of ubiquitin-specific protease activity; IDA:ParkinsonsUK-UCL
GO:2000825; P:positive regulation of androgen receptor activity; IMP:ParkinsonsUK-UCL
GO:1903181; P:positive regulation of dopamine biosynthetic process; IDA:ParkinsonsUK-UCL
GO:0032757; P:positive regulation of interleukin-8 production; IDA:ParkinsonsUK-UCL
GO:1903197; P:positive regulation of L-dopa biosynthetic process; IMP:ParkinsonsUK-UCL
GO:1903200; P:positive regulation of L-dopa decarboxylase activity; IDA:ParkinsonsUK-UCL
GO:1902958; P:positive regulation of mitochondrial electron transport, NADH to ubiquinone; IMP:ParkinsonsUK-UCL
GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IEA:Ensembl
GO:0090073; P:positive regulation of protein homodimerization activity; IDA:ParkinsonsUK-UCL
GO:1900182; P:positive regulation of protein localization to nucleus; IDA:ParkinsonsUK-UCL
GO:1903168; P:positive regulation of pyrroline-5-carboxylate reductase activity; IDA:ParkinsonsUK-UCL
GO:1901671; P:positive regulation of superoxide dismutase activity; IDA:ParkinsonsUK-UCL
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:ParkinsonsUK-UCL
GO:1903178; P:positive regulation of tyrosine 3-monooxygenase activity; IDA:ParkinsonsUK-UCL
GO:0050821; P:protein stabilization; IMP:UniProtKB
GO:0060765; P:regulation of androgen receptor signaling pathway; IDA:UniProtKB
GO:1902903; P:regulation of fibril organization; TAS:ParkinsonsUK-UCL
GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB
GO:0051881; P:regulation of mitochondrial membrane potential; IMP:ParkinsonsUK-UCL
GO:0043523; P:regulation of neuron apoptotic process; IDA:UniProtKB
GO:0007338; P:single fertilization; IEA:UniProtKB-KW

Interpro

InterPro; IPR029062; Class_I_gatase-like
InterPro; IPR006287; DJ1
InterPro; IPR002818; ThiJ/PfpI

Pfam

Pfam; PF01965; DJ-1_PfpI;

SMART

PROSITE

PRINTS