LipidDB ID

LipidDB-9606-00888

Entry Name

UniProt Accession

P61006; B4DEK7; P24407; Q6FHV5;

Theoretical PI

9.15

Molecular Weight

23668.2

Genbank Protein ID

CAA40065.1; AAB19681.1; AAM21091.1; AAP35848.1; BAG57118.1; CAG38820.1; CAG47070.1; EAW84526.1; AAH02977.1;

Genbank Nucleotide ID

X56741; S53268; AF498943; BT007184; AK293676; CR536583; AC008894; CR542274; CH471106; BC002977;

Protein Name

Ras-related protein Rab-8A

Protein Synonyms/Alias

Oncogene c-mel;

Gene Name

RAB8A

Gene Synonyms/Alias

MEL; RAB8;

Created Date

26-APR-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Joberty G, Tavitian A, Zahraoui A. Isoprenylation of Rab proteins possessing aC-terminal CaaX motif. FEBS Lett. 1993 Sep 20;330(3):323-8.[PMID:8375503]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.

Sequence Annotation

Nucleotide-binding: 15 22 GTP.
Nucleotide-binding: 63 67 GTP.
Nucleotide-binding: 121 124 GTP.
Motif: 37 45 Effector region.
Modified residue: 181 181 Phosphoserine.
Modified residue: 185 185 Phosphoserine.
Modified residue: 204 204 Cysteine methyl ester.

Protein Length

207 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005813; C:centrosome; IDA:MGI
GO:0036064; C:ciliary basal body; IEA:Ensembl
GO:0005929; C:cilium; IDA:MGI
GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome
GO:0030425; C:dendrite; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0000139; C:Golgi membrane; TAS:Reactome
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0031513; C:nonmotile primary cilium; IDA:BHF-UCL
GO:0045335; C:phagocytic vesicle; IDA:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0014069; C:postsynaptic density; IEA:Ensembl
GO:0072372; C:primary cilium; IDA:UniProtKB
GO:0055038; C:recycling endosome membrane; IDA:UniProtKB
GO:0030140; C:trans-Golgi network transport vesicle; IEA:Ensembl
GO:0019003; F:GDP binding; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0031489; F:myosin V binding; IPI:UniProtKB
GO:0017137; F:Rab GTPase binding; ISS:UniProtKB
GO:0007409; P:axonogenesis; ISS:UniProtKB
GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB
GO:0042384; P:cilium assembly; IMP:UniProtKB
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome
GO:0048210; P:Golgi vesicle fusion to target membrane; IDA:BHF-UCL
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0061024; P:membrane organization; TAS:Reactome
GO:0000278; P:mitotic cell cycle; TAS:Reactome
GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl
GO:0051223; P:regulation of protein transport; IEA:Ensembl
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0006904; P:vesicle docking involved in exocytosis; IDA:BHF-UCL

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;