Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00884
Entry Name
UniProt Accession
Theoretical PI
7.52
Molecular Weight
21428.81
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Ras-related C3 botulinum toxin substrate 2
Protein Synonyms/Alias
GX; Small G protein; p21-Rac2;
Gene Name
RAC2
Gene Synonyms/Alias
Created Date
01-APR-1990
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
189
Canonical
TRQQKRACSLL****
[1]
S-Geranylgeranylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Kinsella BT, Erdman RA, Maltese WA. Carboxyl-terminal isoprenylation ofras-related GTP-binding proteins encoded by rac1, rac2, and ralA. J Biol Chem.1991 May 25;266(15):9786-94.[PMID:1903399]
Functional Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Sequence Annotation
Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 115 118 GTP.
Motif: 32 40 Effector region.
Modified residue: 39 39 ADP-ribosylasparagine; by botulinumtoxin.
Modified residue: 147 147 N6-acetyllysine.
Modified residue: 189 189 Cysteine methyl ester.
Protein Length
192 AA.
Protein Sequence
(Canonical)
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG  60
QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR  120
DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ  180
PTRQQKRACS LL                                                      192
FASTA
(Canonical)
>LipidDB-9606-00884|P15153
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR
DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ
PTRQQKRACSLL
Gene Ontology
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0030027; C:lamellipodium; IDA:UniProtKB
GO:0005635; C:nuclear envelope; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005525; F:GTP binding; IMP:UniProtKB
GO:0003924; F:GTPase activity; TAS:ProtInc
GO:0007015; P:actin filament organization; IMP:UniProtKB
GO:0007411; P:axon guidance; TAS:Reactome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0045453; P:bone resorption; IEA:Ensembl
GO:0030031; P:cell projection assembly; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:Ensembl
GO:0071593; P:lymphocyte aggregation; IMP:UniProtKB
GO:0030168; P:platelet activation; TAS:Reactome
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0010592; P:positive regulation of lamellipodium assembly; IMP:UniProtKB
GO:0090023; P:positive regulation of neutrophil chemotaxis; IMP:UniProtKB
GO:0010810; P:regulation of cell-substrate adhesion; IMP:UniProtKB
GO:0010310; P:regulation of hydrogen peroxide metabolic process; TAS:BHF-UCL
GO:1902622; P:regulation of neutrophil migration; IMP:UniProtKB
GO:0060263; P:regulation of respiratory burst; IDA:BHF-UCL
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00174; RHO;
PROSITE
PROSITE; PS51420; RHO;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;