LipidDB ID

LipidDB-9606-00883

Entry Name

UniProt Accession

P62330; P26438; Q6FGZ2;

Theoretical PI

9.04

Molecular Weight

20082.16

Genbank Protein ID

AAA90928.1; AAP50257.1; AAC39877.1; AAM12599.1; BAG36527.1; CAG46762.1; EAW65740.1; AAH08918.1;

Genbank Nucleotide ID

M57763; AY296206; AF047432; AF493885; AK313790; CR541964; CH471078; BC002952; BC008918;

Protein Name

ADP-ribosylation factor 6

Protein Synonyms/Alias

Gene Name

ARF6

Gene Synonyms/Alias

Created Date

05-JUL-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] D'Souza-Schorey C, Stahl PD. Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res. 1995 Nov;221(1):153-9.[PMID:7589240]

Functional Description

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.

Sequence Annotation

Nucleotide-binding: 23 28 GTP.
Nucleotide-binding: 41 44 GTP.
Nucleotide-binding: 63 67 GTP.
Nucleotide-binding: 122 125 GTP.
Nucleotide-binding: 155 156 GTP.

Protein Length

175 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005938; C:cell cortex; IDA:UniProtKB
GO:0005769; C:early endosome; IEA:Ensembl
GO:0030139; C:endocytic vesicle; IDA:UniProtKB
GO:0005768; C:endosome; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0031527; C:filopodium membrane; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0055038; C:recycling endosome membrane; IDA:UniProtKB
GO:0001726; C:ruffle; IDA:UniProtKB
GO:0005525; F:GTP binding; TAS:UniProtKB
GO:0003924; F:GTPase activity; TAS:ProtInc
GO:0031996; F:thioesterase binding; IPI:UniProtKB
GO:0007155; P:cell adhesion; TAS:UniProtKB
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0051301; P:cell division; IEA:UniProtKB-KW
GO:0006928; P:cellular component movement; TAS:UniProtKB
GO:0030866; P:cortical actin cytoskeleton organization; IMP:UniProtKB
GO:0090162; P:establishment of epithelial cell polarity; IEA:Ensembl
GO:0006184; P:GTP catabolic process; TAS:GOC
GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl
GO:0001889; P:liver development; IEA:Ensembl
GO:0033028; P:myeloid cell apoptotic process; IEA:Ensembl
GO:0048261; P:negative regulation of receptor-mediated endocytosis; TAS:UniProtKB
GO:0030838; P:positive regulation of actin filament polymerization; IMP:UniProtKB
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; ISS:BHF-UCL
GO:0034394; P:protein localization to cell surface; ISS:BHF-UCL
GO:0036010; P:protein localization to endosome; IMP:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0060998; P:regulation of dendritic spine development; ISS:UniProtKB
GO:0051489; P:regulation of filopodium assembly; IDA:UniProtKB
GO:0035020; P:regulation of Rac protein signal transduction; IDA:UniProtKB
GO:0031529; P:ruffle organization; IDA:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0016192; P:vesicle-mediated transport; TAS:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR024156; Small_GTPase_ARF
InterPro; IPR006689; Small_GTPase_ARF/SAR

Pfam

Pfam; PF00025; Arf;

SMART

SMART; SM00177; ARF;

PROSITE

PROSITE; PS51417; ARF;

PRINTS

PRINTS; PR00328; SAR1GTPBP;