LipidDB ID

LipidDB-9606-00881

Entry Name

UniProt Accession

P51681; O14692; O14693; O14695; O14696; O14697; O14698; O14699; O14700; O14701; O14702; O14703; O14704; O14705; O14706; O14707; O14708; O15538; Q9UPA4;

Theoretical PI

9.21

Molecular Weight

40524.05

Genbank Protein ID

CAA62796.1; AAC50598.1; AAB17071.1; AAC51797.1; AAB65700.1; AAB65701.1; AAB65702.1; AAB65703.1; AAB65705.1; AAB65706.1; AAB65707.1; AAB65708.1; AAB65709.1; AAB65710.1; AAB65711.1; AAB65712.1; AAB65713.1; AAB65714.1; AAB65715.1; AAB65716.1; AAB65717.1; AAB65718.1; AAB65719.1; AAB65720.1; AAB65721.1; AAB65722.1; AAB65723.1; AAB65724.1; AAB65725.1; AAB65726.1; AAB65727.1; AAB65728.1; AAB65729.1; AAB65730.1; AAB65731.1; AAB65732.1; AAB65733.1; AAB65734.1; AAB65735.1; AAB65736.1; AAB65737.1; AAB94735.1; AAD18131.1; AAO65971.1; AAB57793.1; AAH38398.1;

Genbank Nucleotide ID

X91492; U54994; U57840; U83326; AF011500; AF011501; AF011502; AF011503; AF011505; AF011506; AF011507; AF011508; AF011509; AF011510; AF011511; AF011512; AF011513; AF011514; AF011515; AF011516; AF011517; AF011518; AF011519; AF011520; AF011521; AF011522; AF011523; AF011524; AF011525; AF011526; AF011527; AF011528; AF011529; AF011530; AF011531; AF011532; AF011533; AF011534; AF011535; AF011536; AF011537; AF031237; AF052539; AY221093; U95626; BC038398;

Protein Name

C-C chemokine receptor type 5

Protein Synonyms/Alias

C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CHEMR13; HIV-1 fusion coreceptor; CD195;

Gene Name

CCR5

Gene Synonyms/Alias

CMKBR5;

Created Date

01-OCT-1996

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Blanpain C, Wittamer V, Vanderwinden JM, Boom A, Renneboog B, Lee B, Le PoulE, El Asmar L, Govaerts C, Vassart G, Doms RW, Parmentier M. Palmitoylation ofCCR5 is critical for receptor trafficking and efficient activation ofintracellular signaling pathways. J Biol Chem. 2001 Jun 29;276(26):23795-804.Epub 2001 Apr 25.[PMID:11323418]

Functional Description

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Sequence Annotation

Topological domain: 1 30 Extracellular.
Transmembrane: 31 58 Helical; Name=1.
Topological domain: 59 68 Cytoplasmic.
Transmembrane: 69 89 Helical; Name=2.
Topological domain: 90 102 Extracellular.
Transmembrane: 103 124 Helical; Name=3.
Topological domain: 125 141 Cytoplasmic.
Transmembrane: 142 166 Helical; Name=4.
Topological domain: 167 198 Extracellular.
Transmembrane: 199 218 Helical; Name=5.
Topological domain: 219 235 Cytoplasmic.
Transmembrane: 236 260 Helical; Name=6.
Topological domain: 261 277 Extracellular.
Transmembrane: 278 301 Helical; Name=7.
Topological domain: 302 352 Cytoplasmic.
Modified residue: 3 3 Sulfotyrosine.
Modified residue: 10 10 Sulfotyrosine.
Modified residue: 14 14 Sulfotyrosine.
Modified residue: 15 15 Sulfotyrosine.
Modified residue: 336 336 Phosphoserine; by BARK1.
Modified residue: 337 337 Phosphoserine; by BARK1.
Modified residue: 342 342 Phosphoserine; by BARK1.
Modified residue: 349 349 Phosphoserine; by BARK1.

Protein Length

352 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009986; C:cell surface; IDA:UniProtKB
GO:0005737; C:cytoplasm; TAS:ProtInc
GO:0005768; C:endosome; IDA:UniProtKB
GO:0009897; C:external side of plasma membrane; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0003779; F:actin binding; IDA:UniProtKB
GO:0019957; F:C-C chemokine binding; IPI:UniProtKB
GO:0016493; F:C-C chemokine receptor activity; NAS:UniProtKB
GO:0071791; F:chemokine (C-C motif) ligand 5 binding; IPI:UniProtKB
GO:0004950; F:chemokine receptor activity; TAS:ProtInc
GO:0015026; F:coreceptor activity; TAS:ProtInc
GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc
GO:0006816; P:calcium ion transport; IDA:UniProtKB
GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB
GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc
GO:0007267; P:cell-cell signaling; IDA:UniProtKB
GO:0006968; P:cellular defense response; TAS:ProtInc
GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB
GO:0070098; P:chemokine-mediated signaling pathway; IDA:GOC
GO:0006935; P:chemotaxis; TAS:ProtInc
GO:0002407; P:dendritic cell chemotaxis; TAS:BHF-UCL
GO:0030260; P:entry into host cell; TAS:Reactome
GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:UniProtKB
GO:0006955; P:immune response; TAS:ProtInc
GO:0006954; P:inflammatory response; TAS:ProtInc
GO:0000165; P:MAPK cascade; IEP:UniProtKB
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc
GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IDA:UniProtKB
GO:0070723; P:response to cholesterol; IMP:UniProtKB
GO:0023052; P:signaling; IEP:UniProtKB
GO:0016032; P:viral process; TAS:Reactome

Interpro

InterPro; IPR002240; Chemokine_CCR5
InterPro; IPR000355; Chemokine_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00657; CCCHEMOKINER;
PRINTS; PR01110; CHEMOKINER5;
PRINTS; PR00237; GPCRRHODOPSN;