Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00858
Entry Name
UniProt Accession
Theoretical PI
6.66
Molecular Weight
78806.41
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Protein Synonyms/Alias
2.6.1.16; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1;
Gene Name
GFPT1
Gene Synonyms/Alias
GFAT; GFPT;
Created Date
01-JUN-1994
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MCGIFAYLN
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
Sequence Annotation
Domain: 2 305 Glutamine amidotransferase type-2.
Domain: 377 516 SIS 1.
Domain: 548 689 SIS 2.
Region: 313 680 Isomerase.
Region: 394 395 Substrate-binding.
Region: 439 441 Substrate-binding.
Active site: 2 2 For GATase activity.
Binding site: 444 444 Substrate.
Binding site: 584 584 Substrate.
Modified residue: 261 261 Phosphoserine.
Protein Length
699 AA.
Protein Sequence
(Canonical)
MCGIFAYLNY HVPRTRREIL ETLIKGLQRL EYRGYDSAGV GFDGGNDKDW EANACKIQLI  60
KKKGKVKALD EEVHKQQDMD LDIEFDVHLG IAHTRWATHG EPSPVNSHPQ RSDKNNEFIV  120
IHNGIITNYK DLKKFLESKG YDFESETDTE TIAKLVKYMY DNRESQDTSF TTLVERVIQQ  180
LEGAFALVFK SVHFPGQAVG TRRGSPLLIG VRSEHKLSTD HIPILYRTAR TQIGSKFTRW  240
GSQGERGKDK KGSCNLSRVD STTCLFPVEE KAVEYYFASD ASAVIEHTNR VIFLEDDDVA  300
AVVDGRLSIH RIKRTAGDHP GRAVQTLQME LQQIMKGNFS SFMQKEIFEQ PESVVNTMRG  360
RVNFDDYTVN LGGLKDHIKE IQRCRRLILI ACGTSYHAGV ATRQVLEELT ELPVMVELAS  420
DFLDRNTPVF RDDVCFFLSQ SGETADTLMG LRYCKERGAL TVGITNTVGS SISRETDCGV  480
HINAGPEIGV ASTKAYTSQF VSLVMFALMM CDDRISMQER RKEIMLGLKR LPDLIKEVLS  540
MDDEIQKLAT ELYHQKSVLI MGRGYHYATC LEGALKIKEI TYMHSEGILA GELKHGPLAL  600
VDKLMPVIMI IMRDHTYAKC QNALQQVVAR QGRPVVICDK EDTETIKNTK RTIKVPHSVD  660
CLQGILSVIP LQLLAFHLAV LRGYDVDFPR NLAKSVTVE                         699
FASTA
(Canonical)
>LipidDB-9606-00858|Q06210
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGFDGGNDKDWEANACKIQLI
KKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIV
IHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNRESQDTSFTTLVERVIQQ
LEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTRW
GSQGERGKDKKGSCNLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVA
AVVDGRLSIHRIKRTAGDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRG
RVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGVATRQVLEELTELPVMVELAS
DFLDRNTPVFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGV
HINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLS
MDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLAL
VDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVD
CLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
Gene Ontology
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016597; F:amino acid binding; IEA:Ensembl
GO:0030246; F:carbohydrate binding; IEA:Ensembl
GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; TAS:ProtInc
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome
GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro
GO:0044267; P:cellular protein metabolic process; TAS:Reactome
GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl
GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB
GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; TAS:Reactome
GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:Reactome
GO:0006112; P:energy reserve metabolic process; TAS:ProtInc
GO:0006002; P:fructose 6-phosphate metabolic process; TAS:ProtInc
GO:0006042; P:glucosamine biosynthetic process; IEA:Ensembl
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW
GO:0045719; P:negative regulation of glycogen biosynthetic process; IEA:Ensembl
GO:0043687; P:post-translational protein modification; TAS:Reactome
GO:0051289; P:protein homotetramerization; IEA:Ensembl
GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome
GO:0009744; P:response to sucrose; IEA:Ensembl
GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; TAS:Reactome
Interpro
InterPro; IPR017932; GATase_2_dom
InterPro; IPR000583; GATase_dom
InterPro; IPR005855; GlmS_trans
InterPro; IPR029055; Ntn_hydrolases_N
InterPro; IPR001347; SIS
Pfam
Pfam; PF00310; GATase_2;
Pfam; PF01380; SIS;
SMART
PROSITE
PROSITE; PS51278; GATASE_TYPE_2;
PROSITE; PS51464; SIS;
PRINTS