LipidDB ID

LipidDB-9606-00854

Entry Name

UniProt Accession

P32970; B4DPR8; Q53XX4; Q96J57;

Theoretical PI

8.93

Molecular Weight

21118.38

Genbank Protein ID

AAA36175.1; AAB30121.1; AAP35875.1; BAG60680.1; ABK41892.1; EAW69074.1; AAH00725.1;

Genbank Nucleotide ID

L08096; S69339; BT007211; AK298467; EF064709; AC008760; CH471139; BC000725;

Protein Name

CD70 antigen

Protein Synonyms/Alias

CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD70;

Gene Name

CD70

Gene Synonyms/Alias

CD27L; CD27LG; TNFSF7;

Created Date

01-OCT-1993

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Sequence Annotation

Topological domain: 1 17 Cytoplasmic.
Transmembrane: 18 38 Helical; Signal-anchor for type IImembrane protein.
Topological domain: 39 193 Extracellular.

Protein Length

193 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005615; C:extracellular space; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; IDA:HGNC
GO:0002020; F:protease binding; IPI:BHF-UCL
GO:0005102; F:receptor binding; TAS:ProtInc
GO:0008283; P:cell proliferation; TAS:ProtInc
GO:0007267; P:cell-cell signaling; TAS:ProtInc
GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:BHF-UCL
GO:0006955; P:immune response; IEA:InterPro
GO:0007165; P:signal transduction; TAS:ProtInc

Interpro

InterPro; IPR021184; TNF_CS
InterPro; IPR006052; TNF_dom
InterPro; IPR008983; Tumour_necrosis_fac-like_dom

Pfam

Pfam; PF00229; TNF;

SMART

SMART; SM00207; TNF;

PROSITE

PROSITE; PS00251; TNF_1;
PROSITE; PS50049; TNF_2;

PRINTS