LipidDB ID

LipidDB-9606-00851

Entry Name

UniProt Accession

P10966; P14860; P14861; Q15980; Q496E0; Q496E1; Q496E2; Q9UDB4; Q9UDB5; Q9UDB6; Q9UDB7; Q9UDB8; Q9UDB9; Q9UDC0; Q9UQ55;

Theoretical PI

10.03

Molecular Weight

23722.07

Genbank Protein ID

CAA31795.1; CAA31796.1; CAA31797.1; CAA31803.1; CAA68750.1; AAA35664.1; AAB21669.2; AAB21669.2; AAB21669.2; AAB21669.2; AAB21669.2; AAB21670.2; AAB21670.2; AAB21670.2; AAB21670.2; AAB21670.2; AAB21670.2; AAB21671.2; AAB21671.2; AAB21671.2; AAB21671.2; AAB21671.2; AAB21671.2; AAB21672.2; AAB21672.2; AAB21672.2; AAB21672.2; AAB21672.2; AAB21672.2; AAI00912.1; AAI00913.1; AAI00914.1; AAI00915.1; AAD13877.1; AAD13877.1; AAD13877.1;

Genbank Nucleotide ID

X13444; X13445; X13446; X13452; Y00805; M36712; S87090; S87068; S87070; S87073; S87081; S87087; S87068; S87070; S87073; S87078; S87081; S87083; S87068; S87070; S87073; S87078; S87081; S87083; S87068; S87070; S87073; S87078; S87081; AC111200; BC100911; BC100912; BC100913; BC100914; S55731; S55730; S55733;

Protein Name

T-cell surface glycoprotein CD8 beta chain

Protein Synonyms/Alias

CD8b;

Gene Name

CD8B

Gene Synonyms/Alias

CD8B1;

Created Date

01-JUL-1989

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Pang DJ, Hayday AC, Bijlmakers MJ. CD8 Raft localization is induced by itsassembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers. J BiolChem. 2007 May 4;282(18):13884-94. Epub 2007 Mar 6.[PMID:17341584]

Functional Description

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

Sequence Annotation

Topological domain: 22 170 Extracellular.
Transmembrane: 171 191 Helical.
Topological domain: 192 210 Cytoplasmic.
Domain: 22 132 Ig-like V-type.
Modified residue: 209 209 Phosphotyrosine.

Protein Length

210 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0031901; C:early endosome membrane; TAS:Reactome
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0005576; C:extracellular region; IEA:UniProtKB-KW
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0042101; C:T cell receptor complex; NAS:UniProtKB
GO:0015026; F:coreceptor activity; NAS:UniProtKB
GO:0042288; F:MHC class I protein binding; NAS:UniProtKB
GO:0006955; P:immune response; NAS:UniProtKB
GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome
GO:0050776; P:regulation of immune response; TAS:Reactome
GO:0042110; P:T cell activation; NAS:UniProtKB
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB
GO:0016032; P:viral process; TAS:Reactome

Interpro

InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003599; Ig_sub
InterPro; IPR013106; Ig_V-set

Pfam

Pfam; PF07686; V-set;

SMART

SMART; SM00409; IG;

PROSITE

PROSITE; PS50835; IG_LIKE;

PRINTS