LipidDB ID

LipidDB-9606-00842

Entry Name

UniProt Accession

P61224; B2R5Z2; B4DQI8; B4DW74; B4DW94; P09526; Q502X3; Q5TZR4; Q6DCA1; Q6LES0;

Theoretical PI

5.65

Molecular Weight

20824.79

Genbank Protein ID

CAB46488.1; CAB45777.1; BAB93460.1; AAM12627.1; BAG60950.1; BAG62936.1; BAG62956.1; BAG35289.1; CAG28617.1; AAV38896.1; ABQ52130.1; EAW97189.1; AAH00176.1; AAH78173.1; AAH95467.1;

Genbank Nucleotide ID

X08004; AL080212; AB062128; AF493913; AK298818; AK301401; AK301428; AK312371; CR407689; BT020093; EF581377; AC015550; CH471054; BC000176; BC078173; BC095467;

Protein Name

Ras-related protein Rap-1b

Protein Synonyms/Alias

GTP-binding protein smg p21B;

Gene Name

RAP1B

Gene Synonyms/Alias

OK/SW-cl.11;

Created Date

10-MAY-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Kawata M, Farnsworth CC, Yoshida Y, Gelb MH, Glomset JA, Takai Y.Posttranslationally processed structure of the human platelet protein smg p21B:evidence for geranylgeranylation and carboxyl methylation of the C-terminalcysteine. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8960-4.[PMID:2123345]

Functional Description

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.

Sequence Annotation

Nucleotide-binding: 10 18 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Nucleotide-binding: 147 149 GTP.
Region: 25 67 Interaction with KRIT1.
Motif: 32 40 Effector region.
Modified residue: 39 39 ADP-ribosylserine; by botulinum toxin.
Modified residue: 179 179 Phosphoserine; by PKA.
Modified residue: 181 181 Cysteine methyl ester.

Protein Length

184 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005911; C:cell-cell junction; IDA:UniProtKB
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005622; C:intracellular; IDA:LIFEdb
GO:0005811; C:lipid particle; IDA:UniProtKB
GO:0016020; C:membrane; TAS:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0019003; F:GDP binding; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0032403; F:protein complex binding; IDA:MGI
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0008283; P:cell proliferation; IEA:Ensembl
GO:0071320; P:cellular response to cAMP; IDA:UniProtKB
GO:0006112; P:energy reserve metabolic process; TAS:Reactome
GO:0061028; P:establishment of endothelial barrier; IMP:UniProtKB
GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl
GO:2000301; P:negative regulation of synaptic vesicle exocytosis; IEA:Ensembl
GO:0030168; P:platelet activation; TAS:Reactome
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl
GO:0032486; P:Rap protein signal transduction; IMP:UniProtKB
GO:1901888; P:regulation of cell junction assembly; IMP:UniProtKB
GO:2000114; P:regulation of establishment of cell polarity; IMP:UniProtKB
GO:0050796; P:regulation of insulin secretion; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;