Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00824
Entry Name
UniProt Accession
Theoretical PI
9.82
Molecular Weight
48035.18
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Serine/threonine-protein kinase H1
Protein Synonyms/Alias
2.7.11.1; Protein serine kinase H1; PSK-H1;
Gene Name
PSKH1
Gene Synonyms/Alias
Created Date
01-OCT-1989
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGCGTSKVL
[1]
N-Myristoylation
3
Canonical
*****MGCGTSKVLP
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Brede G, Solheim J, Stang E, Prydz H. Mutants of the protein serine kinasePSKH1 disassemble the Golgi apparatus. Exp Cell Res. 2003 Dec 10;291(2):299-312.[PMID:14644153]
Functional Description
May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.
Sequence Annotation
Domain: 98 355 Protein kinase.
Nucleotide-binding: 104 112 ATP.
Active site: 218 218 Proton acceptor.
Binding site: 127 127 ATP.
Modified residue: 380 380 Phosphoserine; by autocatalysis.
Modified residue: 381 381 Phosphoserine; by autocatalysis.
Protein Length
424 AA.
Protein Sequence
(Canonical)
MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA GFPAASQYAH  60
PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT  120
RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL  180
FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF  240
GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD  300
NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA  360
SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ  420
QYNG                                                               424
MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPVKA GFPAASQYAH  60
PCPGPPTAGH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT  120
RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL  180
FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF  240
GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD  300
NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA  360
SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ  420
QYNG                                                               424
FASTA
(Canonical)
>LipidDB-9606-00824|P11801
MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH
PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT
RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL
FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF
GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD
NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA
SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ
QYNG
MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH
PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT
RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL
FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF
GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD
NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA
SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ
QYNG
Gene Ontology
GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW
Interpro
InterPro; IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR002290; Ser/Thr_dual-sp_kinase
InterPro; IPR008271; Ser/Thr_kinase_AS
Pfam
Pfam; PF00069; Pkinase;
SMART
SMART; SM00220; S_TKc;
PROSITE
PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00108; PROTEIN_KINASE_ST;
PRINTS