LipidDB ID

LipidDB-9606-00823

Entry Name

UniProt Accession

P07306; I3L1X1;

Theoretical PI

5.28

Molecular Weight

33186.03

Genbank Protein ID

AAA51785.1; BAB83508.1; ACQ90237.1; AAH32130.1;

Genbank Nucleotide ID

M10058; AB070933; FJ410292; AC120057; BC032130;

Protein Name

Asialoglycoprotein receptor 1

Protein Synonyms/Alias

ASGP-R 1; ASGPR 1; C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1;

Gene Name

ASGR1

Gene Synonyms/Alias

CLEC4H1;

Created Date

01-APR-1988

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Yik JH, Saxena A, Weigel JA, Weigel PH. Nonpalmitoylated humanasialoglycoprotein receptors recycle constitutively but are defective in coatedpit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. JBiol Chem. 2002 Oct 25;277(43):40844-52. Epub 2002 Aug 8.[PMID:12171918]
[2] Yik JH, Saxena A, Weigel JA, Weigel PH. Palmitoylation-defectiveasialoglycoprotein receptors are normal in their cellular distribution andability to bind ligand, but are defective in ligand uptake and degradation.Biochem Biophys Res Commun. 2002 Oct 4;297(4):980-6.[PMID:12359251]
[3] Yik JH, Weigel PH. The position of cysteine relative to the transmembranedomain is critical for palmitoylation of H1, the major subunit of the humanasialoglycoprotein receptor. J Biol Chem. 2002 Dec 6;277(49):47305-12. Epub 2002 Oct 4.[PMID:12370180]

Functional Description

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Sequence Annotation

Topological domain: 1 40 Cytoplasmic.
Transmembrane: 41 61 Helical; Signal-anchor for type IImembrane protein.
Topological domain: 62 291 Extracellular.
Domain: 161 278 C-type lectin.
Motif: 5 8 Endocytosis signal.
Metal binding site: 191 191 Calcium 1; via carbonyl oxygen.
Metal binding site: 197 197 Calcium 1.
Metal binding site: 216 216 Calcium 2.
Metal binding site: 240 240 Calcium 3.
Metal binding site: 242 242 Calcium 3.
Metal binding site: 243 243 Calcium 2.
Metal binding site: 253 253 Calcium 2; via carbonyl oxygen.
Metal binding site: 253 253 Calcium 3.
Metal binding site: 254 254 Calcium 2.
Metal binding site: 265 265 Calcium 3.
Metal binding site: 266 266 Calcium 3.
Metal binding site: 278 278 Calcium 1.
Binding site: 240 240 Carbohydrate.
Binding site: 244 244 Carbohydrate.
Binding site: 253 253 Carbohydrate.

Protein Length

291 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005576; C:extracellular region; IEA:UniProtKB-KW
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0004873; F:asialoglycoprotein receptor activity; TAS:ProtInc
GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl
GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc

Interpro

InterPro; IPR001304; C-type_lectin
InterPro; IPR016186; C-type_lectin-like
InterPro; IPR018378; C-type_lectin_CS
InterPro; IPR016187; C-type_lectin_fold
InterPro; IPR005640; Lectin_N

Pfam

Pfam; PF00059; Lectin_C;
Pfam; PF03954; Lectin_N;

SMART

SMART; SM00034; CLECT;

PROSITE

PROSITE; PS00615; C_TYPE_LECTIN_1;
PROSITE; PS50041; C_TYPE_LECTIN_2;

PRINTS