LipidDB ID

LipidDB-9606-00821

Entry Name

UniProt Accession

P07307; A6NLV8; A8MT12; D3DTM9; D3DTN0; O00448; Q03969;

Theoretical PI

5.81

Molecular Weight

35092.21

Genbank Protein ID

AAB59519.1; AAB58308.1; CAA38997.1; EAW90259.1; EAW90260.1; EAW90261.1; EAW90263.1; AAH17251.1;

Genbank Nucleotide ID

M11025; U97197; X55283; AC120057; CH471108; CH471108; CH471108; CH471108; BC017251;

Protein Name

Asialoglycoprotein receptor 2

Protein Synonyms/Alias

ASGP-R 2; ASGPR 2; C-type lectin domain family 4 member H2; Hepatic lectin H2; HL-2;

Gene Name

ASGR2

Gene Synonyms/Alias

CLEC4H2;

Created Date

01-APR-1988

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Yik JH, Saxena A, Weigel JA, Weigel PH. Nonpalmitoylated humanasialoglycoprotein receptors recycle constitutively but are defective in coatedpit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. JBiol Chem. 2002 Oct 25;277(43):40844-52. Epub 2002 Aug 8.[PMID:12171918]
[2] Yik JH, Saxena A, Weigel JA, Weigel PH. Palmitoylation-defectiveasialoglycoprotein receptors are normal in their cellular distribution andability to bind ligand, but are defective in ligand uptake and degradation.Biochem Biophys Res Commun. 2002 Oct 4;297(4):980-6.[PMID:12359251]

Functional Description

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Sequence Annotation

Topological domain: 1 58 Cytoplasmic.
Transmembrane: 59 79 Helical; Signal-anchor for type IImembrane protein.
Topological domain: 80 311 Extracellular.
Domain: 176 302 C-type lectin.
Motif: 5 8 Endocytosis signal.

Protein Length

311 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0004873; F:asialoglycoprotein receptor activity; TAS:UniProtKB
GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW
GO:0030282; P:bone mineralization; IEA:Ensembl
GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc
GO:0009100; P:glycoprotein metabolic process; IEA:Ensembl
GO:0055088; P:lipid homeostasis; IEA:Ensembl
GO:0006898; P:receptor-mediated endocytosis; TAS:GOC
GO:0031647; P:regulation of protein stability; IEA:Ensembl

Interpro

InterPro; IPR001304; C-type_lectin
InterPro; IPR016186; C-type_lectin-like
InterPro; IPR018378; C-type_lectin_CS
InterPro; IPR016187; C-type_lectin_fold
InterPro; IPR005640; Lectin_N

Pfam

Pfam; PF00059; Lectin_C;
Pfam; PF03954; Lectin_N;

SMART

SMART; SM00034; CLECT;

PROSITE

PROSITE; PS00615; C_TYPE_LECTIN_1;
PROSITE; PS50041; C_TYPE_LECTIN_2;

PRINTS