| Tag |
Content |
LipidDB ID |
LipidDB-9606-00805 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.11 |
Molecular Weight |
66408.34 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Lamin-B1 |
Protein Synonyms/Alias |
|
Gene Name |
LMNB1 |
Gene Synonyms/Alias |
LMN2; LMNB; |
Created Date |
01-FEB-1991 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
583 | Canonical | PRASNRSCAIM**** | [1] | S-Farnesylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Farnsworth CC, Wolda SL, Gelb MH, Glomset JA. Human lamin B contains afarnesylated cysteine residue. J Biol Chem. 1989 Dec 5;264(34):20422-9. PubMedPMID: 2684976; PubMed Central PMCID: PMC3443689.[ PMID:2684976]
|
Functional Description |
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. |
Sequence Annotation |
Domain: 434 546 LTD.
Region: 2 34 Head.
Region: 35 386 Rod.
Region: 35 69 Coil 1A.
Region: 70 81 Linker 1.
Region: 82 215 Coil 1B.
Region: 216 243 Linker 2.
Region: 244 386 Coil 2.
Region: 387 586 Tail.
Motif: 415 420 Nuclear localization signal.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 3 3 Phosphothreonine.
Modified residue: 5 5 Phosphothreonine.
Modified residue: 20 20 Phosphothreonine.
Modified residue: 23 23 Phosphoserine.
Modified residue: 111 111 N6-acetyllysine.
Modified residue: 157 157 N6-acetyllysine.
Modified residue: 210 210 Phosphoserine.
Modified residue: 271 271 N6-acetyllysine.
Modified residue: 330 330 N6-acetyllysine.
Modified residue: 375 375 Phosphoserine.
Modified residue: 483 483 N6-acetyllysine.
Modified residue: 575 575 Phosphothreonine.
Modified residue: 583 583 Cysteine methyl ester.
|
Protein Length |
586 AA. |
Protein Sequence
(Canonical) |
MATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL 60
QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN 120
YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA 180
KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY 240
KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI 300
ESLSSQLSNL QKESRACLER IQELEDLLAK EKDNSRRMLT DKEREMAEIR DQMQQQLNDY 360
EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD 420
VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV 480
SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA 540
QRSTVFKTTI PEEEEEEEEA AGVVVEEELF HQQGTPRASN RSCAIM 586
|
FASTA
(Canonical) |
>LipidDB-9606-00805|P20700
MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSAL
QLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLN
YAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAA
KKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEY
KLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRI
ESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDY
EQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVD
VEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSV
SYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVA
QRSTVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM
|
Gene Ontology |
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Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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