Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00799
Entry Name
UniProt Accession
Theoretical PI
8.32
Molecular Weight
105789.97
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Protein Synonyms/Alias
6.3.4.3; Formyltetrahydrofolate synthetase;
Gene Name
MTHFD1L
Gene Synonyms/Alias
FTHFSDC1;
Created Date
01-JUL-2008
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
238
Canonical
SLEAALQCLFQRKGS
[1]
S-Palmitoylation
451
Canonical
LNVNSFACLRQPSQG
[1]
S-Palmitoylation
961
Canonical
PGLPTRPCFYDIDLD
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.
Sequence Annotation
Nucleotide-binding: 423 430 ATP.
Region: 31 348 Methylenetetrahydrofolate dehydrogenaseand cyclohydrolase.
Region: 349 978 Formyltetrahydrofolate synthetase.
Modified residue: 189 189 N6-acetyllysine; alternate.
Modified residue: 189 189 N6-succinyllysine; alternate.
Modified residue: 596 596 N6-succinyllysine.
Protein Length
978 AA.
Protein Sequence
(Canonical)
MGTRLPLVLR QLRRPPQPPG PPRRLRVPCR ASSGGGGGGG GGREGLLGQR RPQDGQARSS  60
CSPGGRTPAA RDSIVREVIQ NSKEVLSLLQ EKNPAFKPVL AIIQAGDDNL MQEINQNLAE  120
EAGLNITHIC LPPDSSEAEI IDEILKINED TRVHGLALQI SENLFSNKVL NALKPEKDVD  180
GVTDINLGKL VRGDAHECFV SPVAKAVIEL LEKSGVNLDG KKILVVGAHG SLEAALQCLF  240
QRKGSMTMSI QWKTRQLQSK LHEADIVVLG SPKPEEIPLT WIQPGTTVLN CSHDFLSGKV  300
GCGSPRIHFG GLIEEDDVIL LAAALRIQNM VSSGRRWLRE QQHRRWRLHC LKLQPLSPVP  360
SDIEISRGQT PKAVDVLAKE IGLLADEIEI YGKSKAKVRL SVLERLKDQA DGKYVLVAGI  420
TPTPLGEGKS TVTIGLVQAL TAHLNVNSFA CLRQPSQGPT FGVKGGAAGG GYAQVIPMEE  480
FNLHLTGDIH AITAANNLLA AAIDTRILHE NTQTDKALYN RLVPLVNGVR EFSEIQLARL  540
KKLGINKTDP STLTEEEVSK FARLDIDPST ITWQRVLDTN DRFLRKITIG QGNTEKGHYR  600
QAQFDIAVAS EIMAVLALTD SLADMKARLG RMVVASDKSG QPVTADDLGV TGALTVLMKD  660
AIKPNLMQTL EGTPVFVHAG PFANIAHGNS SVLADKIALK LVGEEGFVVT EAGFGADIGM  720
EKFFNIKCRA SGLVPNVVVL VATVRALKMH GGGPSVTAGV PLKKEYTEEN IQLVADGCCN  780
LQKQIQITQL FGVPVVVALN VFKTDTRAEI DLVCELAKRA GAFDAVPCYH WSVGGKGSVD  840
LARAVREAAS KRSRFQFLYD VQVPIVDKIR TIAQAVYGAK DIELSPEAQA KIDRYTQQGF  900
GNLPICMAKT HLSLSHQPDK KGVPRDFILP ISDVRASIGA GFIYPLVGTM STMPGLPTRP  960
CFYDIDLDTE TEQVKGLF                                                978
FASTA
(Canonical)
>LipidDB-9606-00799|Q6UB35
MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSS
CSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFKPVLAIIQAGDDNLMQEINQNLAE
EAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVD
GVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLF
QRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEIPLTWIQPGTTVLNCSHDFLSGKV
GCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVP
SDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGI
TPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEE
FNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARL
KKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYR
QAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKD
AIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGM
EKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCN
LQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVD
LARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGF
GNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRP
CFYDIDLDTETEQVKGLF
Gene Ontology
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005739; C:mitochondrion; IDA:BHF-UCL
GO:0005524; F:ATP binding; IDA:BHF-UCL
GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:BHF-UCL
GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL
GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro
GO:0006760; P:folic acid-containing compound metabolic process; IDA:BHF-UCL
GO:0015942; P:formate metabolic process; IDA:BHF-UCL
GO:0006730; P:one-carbon metabolic process; IBA:RefGenome
GO:0055114; P:oxidation-reduction process; IEA:InterPro
GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway
GO:0046653; P:tetrahydrofolate metabolic process; IDA:BHF-UCL
Interpro
InterPro; IPR000559; Formate_THF_ligase
InterPro; IPR020628; Formate_THF_ligase_CS
InterPro; IPR016040; NAD(P)-bd_dom
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR000672; THF_DH/CycHdrlase
InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom
InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom
Pfam
Pfam; PF01268; FTHFS;
Pfam; PF00763; THF_DHG_CYH;
Pfam; PF02882; THF_DHG_CYH_C;
SMART
PROSITE
PROSITE; PS00721; FTHFS_1;
PROSITE; PS00722; FTHFS_2;
PRINTS
PRINTS; PR00085; THFDHDRGNASE;