Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00798
Entry Name
UniProt Accession
Theoretical PI
8.52
Molecular Weight
39364.76
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein Wnt-3a
Protein Synonyms/Alias
Gene Name
WNT3A
Gene Synonyms/Alias
Created Date
15-JUL-1999
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
77
Canonical
IKIGIQECQHQFRGR
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Doubravska L, Krausova M, Gradl D, Vojtechova M, Tumova L, Lukas J, Valenta T,Pospichalova V, Fafilek B, Plachy J, Sebesta O, Korinek V. Fatty acidmodification of Wnt1 and Wnt3a at serine is prerequisite for lipidation atcysteine and is essential for Wnt signalling. Cell Signal. 2011 May;23(5):837-48.doi: 10.1016/j.cellsig.2011.01.007. Epub 2011 Jan 16.[PMID:21244856]
Functional Description
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Sequence Annotation
Functional site: 26 27 Cleavage; by TIKI1 and TIKI2.
Protein Length
352 AA.
Protein Sequence
(Canonical)
MAPLGYFLLL CSLKQALGSY PIWWSLAVGP QYSSLGSQPI LCASIPGLVP KQLRFCRNYV  60
EIMPSVAEGI KIGIQECQHQ FRGRRWNCTT VHDSLAIFGP VLDKATRESA FVHAIASAGV  120
AFAVTRSCAE GTAAICGCSS RHQGSPGKGW KWGGCSEDIE FGGMVSREFA DARENRPDAR  180
SAMNRHNNEA GRQAIASHMH LKCKCHGLSG SCEVKTCWWS QPDFRAIGDF LKDKYDSASE  240
MVVEKHRESR GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS  300
SHGIDGCDLL CCGRGHNARA ERRREKCRCV FHWCCYVSCQ ECTRVYDVHT CK          352
FASTA
(Canonical)
>LipidDB-9606-00798|P56704
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
Gene Ontology
GO:0009986; C:cell surface; ISS:BHF-UCL
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome
GO:0005576; C:extracellular region; TAS:Reactome
GO:0005615; C:extracellular space; ISS:BHF-UCL
GO:0005796; C:Golgi lumen; TAS:Reactome
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-KW
GO:0005109; F:frizzled binding; IBA:RefGenome
GO:0048018; F:receptor agonist activity; IDA:BHF-UCL
GO:0003713; F:transcription coactivator activity; ISS:BHF-UCL
GO:0090245; P:axis elongation involved in somitogenesis; IEA:Ensembl
GO:0007411; P:axon guidance; IEA:Ensembl
GO:0060070; P:canonical Wnt signaling pathway; IDA:BHF-UCL
GO:0061317; P:canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; IDA:BHF-UCL
GO:0021846; P:cell proliferation in forebrain; ISS:BHF-UCL
GO:0034613; P:cellular protein localization; IEA:Ensembl
GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB
GO:0010387; P:COP9 signalosome assembly; ISS:BHF-UCL
GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl
GO:0030198; P:extracellular matrix organization; IEA:Ensembl
GO:0001947; P:heart looping; IEA:Ensembl
GO:0030097; P:hemopoiesis; IEA:Ensembl
GO:0021766; P:hippocampus development; IEA:Ensembl
GO:0001701; P:in utero embryonic development; IEA:Ensembl
GO:0042472; P:inner ear morphogenesis; IEA:Ensembl
GO:0030879; P:mammary gland development; IEA:Ensembl
GO:0048843; P:negative regulation of axon extension involved in axon guidance; IEA:Ensembl
GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl
GO:0003136; P:negative regulation of heart induction by canonical Wnt signaling pathway; IDA:BHF-UCL
GO:0050768; P:negative regulation of neurogenesis; ISS:BHF-UCL
GO:0010977; P:negative regulation of neuron projection development; ISS:UniProtKB
GO:0030182; P:neuron differentiation; ISS:UniProtKB
GO:0001649; P:osteoblast differentiation; IEA:Ensembl
GO:0060021; P:palate development; IMP:BHF-UCL
GO:0048343; P:paraxial mesodermal cell fate commitment; IEA:Ensembl
GO:0070527; P:platelet aggregation; IEA:Ensembl
GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB
GO:2000081; P:positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation; IEA:Ensembl
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IDA:BHF-UCL
GO:0035413; P:positive regulation of catenin import into nucleus; IDA:BHF-UCL
GO:0008284; P:positive regulation of cell proliferation; ISS:BHF-UCL
GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IEA:Ensembl
GO:0048697; P:positive regulation of collateral sprouting in absence of injury; IEA:Ensembl
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl
GO:0061184; P:positive regulation of dermatome development; IDA:BHF-UCL
GO:0048337; P:positive regulation of mesodermal cell fate specification; IDA:BHF-UCL
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL
GO:0032092; P:positive regulation of protein binding; IDA:BHF-UCL
GO:0001934; P:positive regulation of protein phosphorylation; IDA:BHF-UCL
GO:0061098; P:positive regulation of protein tyrosine kinase activity; IEA:Ensembl
GO:0002092; P:positive regulation of receptor internalization; IDA:BHF-UCL
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL
GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:BHF-UCL
GO:0036342; P:post-anal tail morphogenesis; IEA:Ensembl
GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl
GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl
GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl
GO:0021874; P:Wnt signaling pathway involved in forebrain neuroblast division; IEA:Ensembl
Interpro
InterPro; IPR005817; Wnt
InterPro; IPR009141; Wnt3
InterPro; IPR018161; Wnt_CS
Pfam
Pfam; PF00110; wnt;
SMART
SMART; SM00097; WNT1;
PROSITE
PROSITE; PS00246; WNT1;
PRINTS
PRINTS; PR01843; WNT3PROTEIN;
PRINTS; PR01349; WNTPROTEIN;