LipidDB ID

LipidDB-9606-00793

Entry Name

UniProt Accession

Q12974; A8K9I8; B4DM39; D3DPP0; E9PGJ6; O00649; Q15197; Q15259; Q15260; Q15261; R4GN50;

Theoretical PI

8.67

Molecular Weight

19127.2

Genbank Protein ID

AAA90979.1; AAB40598.1; AAB42169.1; AAB42170.1; AAB39331.1; AAF64264.1; BAF85392.1; BAG59751.1; CAI21726.1; EAX07578.1; EAX07579.1; EAX07582.1; EAX07583.1; AAH70182.1; AAB59575.1;

Genbank Nucleotide ID

U14603; U48297; L48722; L48723; L48937; AF208850; AK292703; AK297280; AL136115; CH471059; CH471059; CH471059; CH471059; BC070182; L39000;

Protein Name

Protein tyrosine phosphatase type IVA 2

Protein Synonyms/Alias

3.1.3.48; HU-PP-1; OV-1; PTP(CAAXII); Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2;

Gene Name

PTP4A2

Gene Synonyms/Alias

PRL2; PTPCAAX2; BM-008;

Created Date

05-JUL-2005

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Cates CA, Michael RL, Stayrook KR, Harvey KA, Burke YD, Randall SK, CrowellPL, Crowell DN. Prenylation of oncogenic human PTP(CAAX) protein tyrosinephosphatases. Cancer Lett. 1996 Dec 20;110(1-2):49-55.[PMID:9018080]
[2] Si X, Zeng Q, Ng CH, Hong W, Pallen CJ. Interaction of farnesylated PRL-2, aprotein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. J Biol Chem. 2001 Aug 31;276(35):32875-82. Epub 2001 Jul 10.[PMID:11447212]

Functional Description

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Sequence Annotation

Domain: 79 145 Tyrosine-protein phosphatase.
Region: 102 107 Phosphate binding.
Active site: 69 69 Proton donor.
Active site: 101 101 Phosphocysteine intermediate.
Binding site: 107 107 Substrate.
Modified residue: 164 164 Cysteine methyl ester.

Protein Length

167 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004727; F:prenylated protein tyrosine phosphatase activity; TAS:ProtInc
GO:0035335; P:peptidyl-tyrosine dephosphorylation; TAS:GOC

Interpro

InterPro; IPR029021; Prot-tyrosine_phosphatase-like
InterPro; IPR000387; Tyr/Dual-sp_Pase
InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt

Pfam

Pfam; PF00102; Y_phosphatase;

SMART

PROSITE

PROSITE; PS50056; TYR_PHOSPHATASE_2;

PRINTS