Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00792
Entry Name
UniProt Accession
Theoretical PI
8.37
Molecular Weight
23318.52
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Claudin-3
Protein Synonyms/Alias
Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1;
Gene Name
CLDN3
Gene Synonyms/Alias
C7orf1; CPETR2;
Created Date
30-MAY-2000
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
181
Canonical
LLGGALLCCSCPPRE
[1]
S-Palmitoylation
182
Canonical
LGGALLCCSCPPREK
[1]
S-Palmitoylation
184
Canonical
GALLCCSCPPREKKY
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity.
Sequence Annotation
Topological domain: 1 8 Cytoplasmic.
Transmembrane: 9 29 Helical.
Topological domain: 30 80 Extracellular.
Transmembrane: 81 101 Helical.
Topological domain: 102 115 Cytoplasmic.
Transmembrane: 116 136 Helical.
Topological domain: 137 159 Extracellular.
Transmembrane: 160 180 Helical.
Topological domain: 181 220 Cytoplasmic.
Region: 219 220 Interactions with TJP1, TJP2 and TJP3.
Modified residue: 198 198 Phosphotyrosine.
Protein Length
220 AA.
Protein Sequence
(Canonical)
MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ  60
MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA  120
GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL  180
CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV                        220
FASTA
(Canonical)
>LipidDB-9606-00792|O15551
MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQ
MQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVA
GVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALL
CCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; TAS:ProtInc
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0016328; C:lateral plasma membrane; IEA:Ensembl
GO:0005923; C:tight junction; IEA:UniProtKB-KW
GO:0005198; F:structural molecule activity; IEA:InterPro
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc
GO:0016338; P:calcium-independent cell-cell adhesion; IEA:Ensembl
GO:0001666; P:response to hypoxia; IEP:UniProtKB
GO:0007165; P:signal transduction; TAS:GOC
Interpro
InterPro; IPR006187; Claudin
InterPro; IPR003549; Claudin3
InterPro; IPR017974; Claudin_CS
InterPro; IPR004031; PMP22/EMP/MP20/Claudin
Pfam
Pfam; PF00822; PMP22_Claudin;
SMART
PROSITE
PROSITE; PS01346; CLAUDIN;
PRINTS
PRINTS; PR01077; CLAUDIN;
PRINTS; PR01378; CLAUDIN3;