Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00773
Entry Name
UniProt Accession
Theoretical PI
9.46
Molecular Weight
46258.76
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Neurotensin receptor type 1
Protein Synonyms/Alias
NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH;
Gene Name
NTSR1
Gene Synonyms/Alias
NTRR;
Created Date
01-JUL-1993
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
381
Canonical
IFLATLACLCPVWRR
[1]
S-Palmitoylation
383
Canonical
LATLACLCPVWRRRR
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Heakal Y, Woll MP, Fox T, Seaton K, Levenson R, Kester M. Neurotensinreceptor-1 inducible palmitoylation is required for efficient receptor-mediatedmitogenic-signaling within structured membrane microdomains. Cancer Biol Ther.2011 Sep 1;12(5):427-35. Epub 2011 Sep 1.[PMID:21725197]
Functional Description
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.
Sequence Annotation
Topological domain: 1 67 Extracellular.
Transmembrane: 68 88 Helical; Name=1.
Topological domain: 89 102 Cytoplasmic.
Transmembrane: 103 122 Helical; Name=2.
Topological domain: 123 142 Extracellular.
Transmembrane: 143 164 Helical; Name=3.
Topological domain: 165 187 Cytoplasmic.
Transmembrane: 188 209 Helical; Name=4.
Topological domain: 210 234 Extracellular.
Transmembrane: 235 259 Helical; Name=5.
Topological domain: 260 303 Cytoplasmic.
Transmembrane: 304 325 Helical; Name=6.
Topological domain: 326 343 Extracellular.
Transmembrane: 344 364 Helical; Name=7.
Topological domain: 365 418 Cytoplasmic.
Region: 321 344 Neurotensin binding.
Protein Length
418 AA.
Protein Sequence
(Canonical)
MRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP SSELDVNTDI  60
YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLTLLLAM  120
PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM  180
SRSRTKKFIS AIWLASALLA VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN  240
TFMSFIFPMV VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH  300
GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN ALFYVSSTIN  360
PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD SVSSNHTLSS NATRETLY    418
FASTA
(Canonical)
>LipidDB-9606-00773|P30989
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
Gene Ontology
GO:0005783; C:endoplasmic reticulum; TAS:ProtInc
GO:0005794; C:Golgi apparatus; TAS:ProtInc
GO:0005887; C:integral component of plasma membrane; IMP:UniProtKB
GO:0045121; C:membrane raft; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0016492; F:G-protein coupled neurotensin receptor activity; IDA:UniProtKB
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc
GO:0008344; P:adult locomotory behavior; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB
GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB
GO:0007268; P:synaptic transmission; TAS:ProtInc
Interpro
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR003985; NT1_rcpt
InterPro; IPR003984; NT_rcpt
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR01479; NEUROTENSINR;
PRINTS; PR01480; NEUROTENSN1R;