LipidDB ID

LipidDB-9606-00772

Entry Name

UniProt Accession

P50150;

Theoretical PI

6.55

Molecular Weight

8388.73

Genbank Protein ID

AAC50204.1; AAM12586.1; AAH22485.1;

Genbank Nucleotide ID

U31382; AF493872; BC022485;

Protein Name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Protein Synonyms/Alias

Gene Name

GNG4

Gene Synonyms/Alias

GNGT4;

Created Date

01-OCT-1996

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Ray K, Kunsch C, Bonner LM, Robishaw JD. Isolation of cDNA clones encodingeight different human G protein gamma subunits, including three novel formsdesignated the gamma 4, gamma 10, and gamma 11 subunits. J Biol Chem. 1995 Sep15;270(37):21765-71.[PMID:7665596]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Sequence Annotation

Modified residue: 72 72 Cysteine methyl ester.

Protein Length

75 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW
GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome
GO:0006112; P:energy reserve metabolic process; TAS:Reactome
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL
GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0007268; P:synaptic transmission; TAS:Reactome

Interpro

InterPro; IPR015898; G-protein_gamma-like_dom
InterPro; IPR001770; Gprotein-gamma

Pfam

Pfam; PF00631; G-gamma;

SMART

SMART; SM00224; GGL;

PROSITE

PROSITE; PS50058; G_PROTEIN_GAMMA;

PRINTS

PRINTS; PR00321; GPROTEING;