| Tag |
Content |
LipidDB ID |
LipidDB-9606-00749 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.2 |
Molecular Weight |
62167.96 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
TBC1 domain family member 3 |
Protein Synonyms/Alias |
Prostate cancer gene 17 protein; Protein TRE17-alpha; Rab GTPase-activating protein PRC17; |
Gene Name |
TBC1D3 |
Gene Synonyms/Alias |
PRC17; TBC1D3A; |
Created Date |
03-OCT-2003 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
318 | Canonical | RLTKTSRCGPWARFC | [1] | S-Palmitoylation | 325 | Canonical | CGPWARFCNRFVDTW | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Kong C, Lange JJ, Samovski D, Su X, Liu J, Sundaresan S, Stahl PD.Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 isregulated by protein palmitoylation. Biochem Biophys Res Commun. 2013 May3;434(2):388-93. doi: 10.1016/j.bbrc.2013.04.001. Epub 2013 Apr 8.[ PMID:23578663]
|
Functional Description |
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. |
Sequence Annotation |
Domain: 101 293 Rab-GAP TBC.
|
Protein Length |
549 AA. |
Protein Sequence
(Canonical) |
MDVVEVAGSW WAQEREDIIM KYEKGHRAGL PEDKGPKPFR SYNNNVDHLG IVHETELPPL 60
TAREAKQIRR EISRKSKWVD MLGDWEKYKS SRKLIDRAYK GMPMNIRGPM WSVLLNIEEM 120
KLKNPGRYQI MKEKGKRSSE HIQRIDRDVS GTLRKHIFFR DRYGTKQREL LHILLAYEEY 180
NPEVGYCRDL SHIAALFLLY LPEEDAFWAL VQLLASERHS LQGFHSPNGG TVQGLQDQQE 240
HVVATSQPKT MGHQDKKDLC GQCSPLGCLI RILIDGISLG LTLRLWDVYL VEGEQALMPI 300
TRIAFKVQQK RLTKTSRCGP WARFCNRFVD TWARDEDTVL KHLRASMKKL TRKQGDLPPP 360
AKPEQGSSAS RPVPASRGGK TLCKGDRQAP PGPPARFPRP IWSASPPRAP RSSTPCPGGA 420
VREDTYPVGT QGVPSPALAQ GGPQGSWRFL QWNSMPRLPT DLDVEGPWFR HYDFRQSCWV 480
RAISQEDQLA PCWQAEHPAE RVRSAFAAPS TDSDQGTPFR ARDEQPCAPT SGPCLCGLHL 540
ESSQFPPGF 549
|
FASTA
(Canonical) |
>LipidDB-9606-00749|Q8IZP1
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPL
TAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEM
KLKNPGRYQIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEY
NPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQE
HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI
TRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPP
AKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGA
VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWV
RAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQPCAPTSGPCLCGLHL
ESSQFPPGF
|
Gene Ontology |
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW GO:0005097; F:Rab GTPase activator activity; IEA:InterPro |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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