| Tag |
Content |
LipidDB ID |
LipidDB-9606-00747 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.58 |
Molecular Weight |
50494.95 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Serine incorporator 1 |
Protein Synonyms/Alias |
Tumor differentially expressed protein 1-like; Tumor differentially expressed protein 2; |
Gene Name |
SERINC1 |
Gene Synonyms/Alias |
KIAA1253; TDE1L; TDE2; UNQ396/PRO732; |
Created Date |
25-NOV-2002 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGSVLGLCS | [1] | N-Myristoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Suzuki T, Moriya K, Nagatoshi K, Ota Y, Ezure T, Ando E, Tsunasawa S, UtsumiT. Strategy for comprehensive identification of human N-myristoylated proteinsusing an insect cell-free protein synthesis system. Proteomics. 2010May;10(9):1780-93. doi: 10.1002/pmic.200900783.[ PMID:20213681]
|
Functional Description |
Enhances the incorporation of serine into phosphatidylserine and sphingolipids. |
Sequence Annotation |
Topological domain: 2 39 Cytoplasmic.
Transmembrane: 40 60 Helical.
Topological domain: 61 88 Lumenal.
Transmembrane: 89 109 Helical.
Topological domain: 110 123 Cytoplasmic.
Transmembrane: 124 144 Helical.
Topological domain: 145 151 Lumenal.
Transmembrane: 152 172 Helical.
Topological domain: 173 197 Cytoplasmic.
Transmembrane: 198 218 Helical.
Topological domain: 219 231 Lumenal.
Transmembrane: 232 252 Helical.
Topological domain: 253 259 Cytoplasmic.
Transmembrane: 260 280 Helical.
Topological domain: 281 309 Lumenal.
Transmembrane: 310 330 Helical.
Topological domain: 331 387 Cytoplasmic.
Transmembrane: 388 408 Helical.
Topological domain: 409 426 Lumenal.
Transmembrane: 427 447 Helical.
Topological domain: 448 453 Cytoplasmic.
Modified residue: 351 351 Phosphoserine.
Modified residue: 352 352 Phosphothreonine.
Modified residue: 361 361 Phosphoserine.
Modified residue: 364 364 Phosphoserine.
|
Protein Length |
453 AA. |
Protein Sequence
(Canonical) |
MGSVLGLCSM ASWIPCLCGS APCLLCRCCP SGNNSTVTRL IYALFLLVGV CVACVMLIPG 60
MEEQLNKIPG FCENEKGVVP CNILVGYKAV YRLCFGLAMF YLLLSLLMIK VKSSSDPRAA 120
VHNGFWFFKF AAAIAIIIGA FFIPEGTFTT VWFYVGMAGA FCFILIQLVL LIDFAHSWNE 180
SWVEKMEEGN SRCWYAALLS ATALNYLLSL VAIVLFFVYY THPASCSENK AFISVNMLLC 240
VGASVMSILP KIQESQPRSG LLQSSVITVY TMYLTWSAMT NEPETNCNPS LLSIIGYNTT 300
STVPKEGQSV QWWHAQGIIG LILFLLCVFY SSIRTSNNSQ VNKLTLTSDE STLIEDGGAR 360
SDGSLEDGDD VHRAVDNERD GVTYSYSFFH FMLFLASLYI MMTLTNWYRY EPSREMKSQW 420
TAVWVKISSS WIGIVLYVWT LVAPLVLTNR DFD 453
|
FASTA
(Canonical) |
>LipidDB-9606-00747|Q9NRX5
MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPG
MEEQLNKIPGFCENEKGVVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSSDPRAA
VHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNE
SWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLC
VGASVMSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSIIGYNTT
STVPKEGQSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTLTSDESTLIEDGGAR
SDGSLEDGDDVHRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWYRYEPSREMKSQW
TAVWVKISSSWIGIVLYVWTLVAPLVLTNRDFD
|
Gene Ontology |
GO:0005789; C:endoplasmic reticulum membrane; ISS:HGNC GO:0070062; C:extracellular vesicular exosome; IDA:UniProt GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; ISS:HGNC GO:0015194; F:L-serine transmembrane transporter activity; ISS:HGNC GO:0015825; P:L-serine transport; ISS:HGNC GO:0006658; P:phosphatidylserine metabolic process; ISS:HGNC GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW GO:0051347; P:positive regulation of transferase activity; ISS:HGNC GO:0006665; P:sphingolipid metabolic process; ISS:HGNC |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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