LipidDB ID

LipidDB-9606-00746

Entry Name

UniProt Accession

P30518; C5HF20; O43192; Q3MJD3; Q9UCV9;

Theoretical PI

9.49

Molecular Weight

40279.09

Genbank Protein ID

AAA03651.1; CAA77746.1; AAC09005.1; AAB86428.1; AAD16444.1; AAB87678.1; AAO92298.1; ACR39021.1; EAW72783.1; EAW72784.1; EAW72785.1; AAI01485.1; AAI12182.1;

Genbank Nucleotide ID

L22206; Z11687; U04357; AF030626; AF101727; AF032388; AY242131; FJ411207; CH471172; CH471172; CH471172; BC101484; BC112181;

Protein Name

Vasopressin V2 receptor

Protein Synonyms/Alias

V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor;

Gene Name

AVPR2

Gene Synonyms/Alias

ADHR; DIR; DIR3; V2R;

Created Date

01-APR-1993

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Charest PG, Bouvier M. Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances beta-arrestin recruitment leading to efficient receptor endocytosisand ERK1/2 activation. J Biol Chem. 2003 Oct 17;278(42):41541-51. Epub 2003 Aug4.[PMID:12900404]

Functional Description

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.

Sequence Annotation

Topological domain: 1 38 Extracellular.
Transmembrane: 39 63 Helical; Name=1.
Topological domain: 64 77 Cytoplasmic.
Transmembrane: 78 98 Helical; Name=2.
Topological domain: 99 113 Extracellular.
Transmembrane: 114 135 Helical; Name=3.
Topological domain: 136 159 Cytoplasmic.
Transmembrane: 160 180 Helical; Name=4.
Topological domain: 181 200 Extracellular.
Transmembrane: 201 220 Helical; Name=5.
Topological domain: 221 271 Cytoplasmic.
Transmembrane: 272 293 Helical; Name=6.
Topological domain: 294 308 Extracellular.
Transmembrane: 309 328 Helical; Name=7.
Topological domain: 329 371 Cytoplasmic.

Protein Length

371 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005783; C:endoplasmic reticulum; TAS:ProtInc
GO:0005768; C:endosome; TAS:ProtInc
GO:0005794; C:Golgi apparatus; TAS:ProtInc
GO:0016021; C:integral component of membrane; NAS:UniProtKB
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005000; F:vasopressin receptor activity; TAS:UniProtKB
GO:0007190; P:activation of adenylate cyclase activity; TAS:ProtInc
GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0007588; P:excretion; TAS:ProtInc
GO:0007599; P:hemostasis; TAS:ProtInc
GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl
GO:0032609; P:interferon-gamma production; IEA:Ensembl
GO:0035814; P:negative regulation of renal sodium excretion; IEA:Ensembl
GO:0035811; P:negative regulation of urine volume; IEA:Ensembl
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB
GO:0031398; P:positive regulation of protein ubiquitination; NAS:BHF-UCL
GO:0003084; P:positive regulation of systemic arterial blood pressure; IEA:Ensembl
GO:0034097; P:response to cytokine; IEA:Ensembl
GO:0021537; P:telencephalon development; IEA:Ensembl
GO:0055085; P:transmembrane transport; TAS:Reactome
GO:0006833; P:water transport; TAS:Reactome

Interpro

InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR001817; Vasoprsn_rcpt
InterPro; IPR000161; Vprsn_rcpt_V2

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR00896; VASOPRESSINR;
PRINTS; PR00898; VASOPRSNV2R;