LipidDB ID

LipidDB-9606-00730

Entry Name

UniProt Accession

Q7L0Q8; B1AKN1; Q59FE9; Q8TDQ2;

Theoretical PI

8.39

Molecular Weight

28218.27

Genbank Protein ID

AAK83340.1; BAB86361.1; BAB18638.1; ABD48870.1; ABD48871.1; ABD48872.1; ABD48873.1; ABD48874.1; ABD48875.1; AAL54874.1; AAG46058.1; AAL99390.1; BAF82660.1; BAD92748.1; CAC00584.1; EAW69885.1; AAH40076.1;

Genbank Nucleotide ID

AF378087; AB074878; AB051826; DQ384420; DQ384421; DQ384422; DQ384423; DQ384424; DQ384425; AF211836; AF282258; AF251701; AK289971; AB209511; AL096776; CH471098; BC040076;

Protein Name

Rho-related GTP-binding protein RhoU

Protein Synonyms/Alias

CDC42-like GTPase 1; GTP-binding protein-like 1; Rho GTPase-like protein ARHU; Ryu GTPase; Wnt-1 responsive Cdc42 homolog 1; WRCH-1;

Gene Name

RHOU

Gene Synonyms/Alias

ARHU; GN CDC42L1; GN G28K; GN WRCH1; SB128;

Created Date

18-MAR-2008

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Berzat AC, Buss JE, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD. Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. J BiolChem. 2005 Sep 23;280(38):33055-65. Epub 2005 Jul 26.[PMID:16046391]

Functional Description

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Sequence Annotation

Nucleotide-binding: 56 63 GTP.
Nucleotide-binding: 103 107 GTP.
Nucleotide-binding: 161 164 GTP.

Protein Length

258 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0042995; C:cell projection; IEA:UniProtKB-KW
GO:0005829; C:cytosol; TAS:Reactome
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IEA:Ensembl
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl
GO:0007010; P:cytoskeleton organization; IMP:UniProtKB
GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl
GO:0016601; P:Rac protein signal transduction; IEA:Ensembl
GO:0008360; P:regulation of cell shape; IMP:UniProtKB
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome
GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003578; Small_GTPase_Rho

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00174; RHO;

PROSITE

PROSITE; PS51420; RHO;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;