Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00729
Entry Name
UniProt Accession
Theoretical PI
7.46
Molecular Weight
26995.22
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
E3 ubiquitin-protein ligase MARCH2
Protein Synonyms/Alias
6.3.2.-; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172;
Gene Name
MARCH2
Gene Synonyms/Alias
RNF172; HSPC240;
Created Date
04-JAN-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
6
Canonical
**MTTGDCCHLPGSL
[1]
S-Palmitoylation
7
Canonical
*MTTGDCCHLPGSLC
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
Sequence Annotation
Transmembrane: 138 158 Helical.
Transmembrane: 175 195 Helical.
Protein Length
246 AA.
Protein Sequence
(Canonical)
MTTGDCCHLP GSLCDCSGSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALDTPSD  60
GPFCRICHEG ANGECLLSPC GCTGTLGAVH KSCLEKWLSS SNTSYCELCH TEFAVEKRPR  120
PLTEWLKDPG PRTEKRTLCC DMVCFLFITP LAAISGWLCL RGAQDHLRLH SQLEAVGLIA  180
LTIALFTIYV LWTLVSFRYH CQLYSEWRKT NQKVRLKIRE ADSPEGPQHS PLAAGLLKKV  240
AEETPV                                                             246
FASTA
(Canonical)
>LipidDB-9606-00729|Q9P0N8
MTTGDCCHLPGSLCDCSGSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSD
GPFCRICHEGANGECLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPR
PLTEWLKDPGPRTEKRTLCCDMVCFLFITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIA
LTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADSPEGPQHSPLAAGLLKKV
AEETPV
Gene Ontology
GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005764; C:lysosome; IEA:UniProtKB-KW
GO:0016874; F:ligase activity; IEA:UniProtKB-KW
GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB
GO:0008270; F:zinc ion binding; IEA:InterPro
GO:0006897; P:endocytosis; IEA:UniProtKB-KW
GO:0016567; P:protein ubiquitination; IDA:UniProtKB
Interpro
InterPro; IPR011016; Znf_RING-CH
InterPro; IPR013083; Znf_RING/FYVE/PHD
Pfam
Pfam; PF12906; RINGv;
SMART
SMART; SM00744; RINGv;
PROSITE
PROSITE; PS51292; ZF_RING_CH;
PRINTS