LipidDB ID

LipidDB-9606-00728

Entry Name

UniProt Accession

P61020; A8K982; B4DKD7; P35239; P35277; Q6PIK9; Q86TH0; Q8IXL2;

Theoretical PI

8.29

Molecular Weight

23706.81

Genbank Protein ID

CAA38653.1; AAM21085.1; BAF85286.1; BAG59149.1; CAD97650.1; EAW96862.1; EAW96864.1; AAH32740.1; AAH40143.1; AAH50558.2; AAH56422.2; AAH65298.2;

Genbank Nucleotide ID

X54871; AF498937; AK292597; AK296517; BX537408; AC034102; CH471054; CH471054; BC032740; BC040143; BC050558; BC056422; BC065298;

Protein Name

Ras-related protein Rab-5B

Protein Synonyms/Alias

Gene Name

RAB5B

Gene Synonyms/Alias

Created Date

26-APR-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Watanabe M, Fiji HD, Guo L, Chan L, Kinderman SS, Slamon DJ, Kwon O, TamanoiF. Inhibitors of protein geranylgeranyltransferase I and Rabgeranylgeranyltransferase identified from a library of allenoate-derivedcompounds. J Biol Chem. 2008 Apr 11;283(15):9571-9. doi: 10.1074/jbc.M706229200. Epub 2008 Jan 28.[PMID:18230616]

Functional Description

Protein transport. Probably involved in vesicular traffic (By similarity).

Sequence Annotation

Nucleotide-binding: 27 35 GTP.
Nucleotide-binding: 75 79 GTP.
Nucleotide-binding: 133 136 GTP.
Nucleotide-binding: 163 165 GTP.
Motif: 49 57 Effector region.
Modified residue: 2 2 N-acetylthreonine.

Protein Length

215 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030139; C:endocytic vesicle; IEA:Ensembl
GO:0005768; C:endosome; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005622; C:intracellular; IDA:LIFEdb
GO:0016020; C:membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:ProtInc
GO:0019003; F:GDP binding; IDA:UniProtKB
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0019882; P:antigen processing and presentation; IMP:UniProt
GO:0007032; P:endosome organization; IEA:Ensembl
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0048227; P:plasma membrane to endosome transport; IMP:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0030100; P:regulation of endocytosis; IEA:Ensembl
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;