Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00720
Entry Name
UniProt Accession
Theoretical PI
8.28
Molecular Weight
20910.01
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Dual specificity protein phosphatase 22
Protein Synonyms/Alias
3.1.3.16; 3.1.3.48; JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x;
Gene Name
DUSP22
Gene Synonyms/Alias
JSP1; LMWDSP2; MKPX;
Created Date
27-JUN-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGNGMNKIL
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Schwertassek U, Buckley DA, Xu CF, Lindsay AJ, McCaffrey MW, Neubert TA, TonksNK. Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase(JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis. FEBS J. 2010 Jun;277(11):2463-73. doi:10.1111/j.1742-4658.2010.07661.x.[PMID:20553486]
Functional Description
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity).
Sequence Annotation
Domain: 65 133 Tyrosine-protein phosphatase.
Active site: 88 88 Phosphocysteine intermediate.
Protein Length
184 AA.
Protein Sequence
(Canonical)
MGNGMNKILP GLYIGNFKDA RDAEQLSKNK VTHILSVHDS ARPMLEGVKY LCIPAADSPS  60
QNLTRHFKES IKFIHECRLR GESCLVHCLA GVSRSVTLVI AYIMTVTDFG WEDALHTVRA  120
GRSCANPNVG FQRQLQEFEK HEVHQYRQWL KEEYGESPLQ DAEEAKNILA APGILKFWAF  180
LRRL                                                               184
FASTA
(Canonical)
>LipidDB-9606-00720|Q9NRW4
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPS
QNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRA
GRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAF
LRRL
Gene Ontology
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome
GO:0006915; P:apoptotic process; TAS:ProtInc
GO:0008283; P:cell proliferation; TAS:ProtInc
GO:0000188; P:inactivation of MAPK activity; TAS:ProtInc
GO:0007275; P:multicellular organismal development; TAS:ProtInc
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI
GO:0046330; P:positive regulation of JNK cascade; IBA:RefGenome
GO:0006470; P:protein dephosphorylation; IBA:RefGenome
GO:0042127; P:regulation of cell proliferation; IBA:RefGenome
GO:0007179; P:transforming growth factor beta receptor signaling pathway; IBA:RefGenome
Interpro
InterPro; IPR020417; Atypical_DUSP
InterPro; IPR000340; Dual-sp_phosphatase_cat-dom
InterPro; IPR020422; Dual-sp_phosphatase_subgr_cat
InterPro; IPR024950; DUSP
InterPro; IPR029021; Prot-tyrosine_phosphatase-like
InterPro; IPR000387; Tyr/Dual-sp_Pase
Pfam
Pfam; PF00782; DSPc;
SMART
SMART; SM00195; DSPc;
PROSITE
PROSITE; PS50056; TYR_PHOSPHATASE_2;
PROSITE; PS50054; TYR_PHOSPHATASE_DUAL;
PRINTS
PRINTS; PR01908; ADSPHPHTASE;