LipidDB ID

LipidDB-9606-00711

Entry Name

UniProt Accession

P17181; B2R6L9; B4DNT3; D3DSF0; Q53GW9; Q53H11; Q6PKD7; Q7M4L2; Q8WTZ2;

Theoretical PI

5.58

Molecular Weight

63525.34

Genbank Protein ID

AAA52730.1; CAA42992.1; BAG60345.1; BAG35516.1; BAD96490.1; BAD96532.1; AAT49100.1; EAX09837.1; EAX09839.1; AAH02590.1; AAH21825.1;

Genbank Nucleotide ID

J03171; X60459; AK298051; AK312631; AK222770; AK222812; AY654286; AF039907; AP000296; AP000297; AP000298; CH471079; CH471079; BC002590; BC021825;

Protein Name

Interferon alpha/beta receptor 1

Protein Synonyms/Alias

IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1;

Gene Name

IFNAR1

Gene Synonyms/Alias

IFNAR;

Created Date

01-AUG-1990

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Claudinon J, Gonnord P, Beslard E, Marchetti M, Mitchell K, Boularan C,Johannes L, Eid P, Lamaze C. Palmitoylation of interferon-alpha (IFN-alpha)receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 byIFN-alpha. J Biol Chem. 2009 Sep 4;284(36):24328-40. doi:10.1074/jbc.M109.021915. Epub 2009 Jun 26.[PMID:19561067]

Functional Description

Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

Sequence Annotation

Topological domain: 28 436 Extracellular.
Transmembrane: 437 457 Helical.
Topological domain: 458 557 Cytoplasmic.
Domain: 32 126 Fibronectin type-III 1.
Domain: 127 227 Fibronectin type-III 2.
Domain: 231 329 Fibronectin type-III 3.
Domain: 331 432 Fibronectin type-III 4.
Modified residue: 466 466 Phosphotyrosine; by TYK2.
Modified residue: 481 481 Phosphotyrosine; by TYK2.
Modified residue: 495 495 Phosphoserine.

Protein Length

557 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004905; F:type I interferon receptor activity; TAS:ProtInc
GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc
GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome
GO:0051607; P:defense response to virus; IEA:Ensembl
GO:0007259; P:JAK-STAT cascade; TAS:ProtInc
GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl
GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl
GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome
GO:0009615; P:response to virus; TAS:ProtInc
GO:0042110; P:T cell activation; IEA:Ensembl
GO:0045351; P:type I interferon biosynthetic process; IEA:Ensembl
GO:0060337; P:type I interferon signaling pathway; TAS:Reactome

Interpro

InterPro; IPR003961; Fibronectin_type3
InterPro; IPR013783; Ig-like_fold
InterPro; IPR016669; Interferon_alpha/beta_rcpt-1
InterPro; IPR015373; Interferon_alpha/beta_rcpt_bsu

Pfam

Pfam; PF09294; Interfer-bind;
Pfam; PF01108; Tissue_fac;

SMART

SMART; SM00060; FN3;

PROSITE

PROSITE; PS50853; FN3;

PRINTS