LipidDB ID

LipidDB-9606-00709

Entry Name

UniProt Accession

P20340; A8K133; B7Z772; F5H668; Q1W5D8; Q5U0A8; Q9UBE4;

Theoretical PI

5.42

Molecular Weight

23592.78

Genbank Protein ID

AAA60246.1; AAD25535.1; AAF23593.1; AAF73841.1; AAD27707.1; ABD93919.1; BAB71371.1; BAF82437.1; BAF82821.1; BAH13508.1; AAM21087.1; AAM21089.1; AAV38504.1; AAH03617.1; AAH68486.1; AAH96818.1;

Genbank Nucleotide ID

M28212; AF130986; AF119836; AF198616; AF130122; DQ437503; AK057157; AK289748; AK290132; AK301534; AF498939; AF498941; BT019698; AP002770; AP002993; BC003617; BC068486; BC096818;

Protein Name

Ras-related protein Rab-6A

Protein Synonyms/Alias

Rab-6;

Gene Name

RAB6A

Gene Synonyms/Alias

RAB6;

Created Date

01-FEB-1991

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Khosravi-Far R, Lutz RJ, Cox AD, Conroy L, Bourne JR, Sinensky M, Balch WE,Buss JE, Der CJ. Isoprenoid modification of rab proteins terminating in CC or CXCmotifs. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6264-8.[PMID:1648736]

Functional Description

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.

Sequence Annotation

Nucleotide-binding: 20 28 GTP.
Nucleotide-binding: 68 72 GTP.
Nucleotide-binding: 126 129 GTP.
Nucleotide-binding: 156 158 GTP.
Motif: 42 50 Effector region.
Modified residue: 2 2 N-acetylserine.
Modified residue: 82 82 O-AMP-tyrosine; by Legionella DrrA.
Modified residue: 208 208 Cysteine methyl ester.

Protein Length

208 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0031410; C:cytoplasmic vesicle; IDA:BHF-UCL
GO:0005829; C:cytosol; IDA:BHF-UCL
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0016020; C:membrane; IDA:BHF-UCL
GO:0005802; C:trans-Golgi network; IDA:BHF-UCL
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0031489; F:myosin V binding; IPI:UniProtKB
GO:0019904; F:protein domain specific binding; IPI:BHF-UCL
GO:0019882; P:antigen processing and presentation; IMP:UniProt
GO:0034498; P:early endosome to Golgi transport; IMP:UniProtKB
GO:0006184; P:GTP catabolic process; IDA:GOC
GO:0072385; P:minus-end-directed organelle transport along microtubule; TAS:BHF-UCL
GO:0018125; P:peptidyl-cysteine methylation; IDA:MGI
GO:0034067; P:protein localization to Golgi apparatus; IDA:BHF-UCL
GO:0000042; P:protein targeting to Golgi; IDA:UniProtKB
GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; TAS:BHF-UCL
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;