LipidDB-9606-00685

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00685

Entry Name

FLOT1_HUMAN

UniProt Accession

O75955; B4DVY7; Q969J8; Q9UHW1; Q9UNV8;

Theoretical PI

7.08

Molecular Weight

47355.28

Genbank Protein ID

AAC35387.1; AAD40192.1; BAB63320.1; BAG62849.1; AAH01146.1; AAF17215.1;

Genbank Nucleotide ID

AF089750; AF085357; BA000025; AK301291; AL662797; BC001146; AF117234;

Protein Name

Flotillin-1

Protein Synonyms/Alias

Gene Name

FLOT1

Gene Synonyms/Alias

Created Date

21-FEB-2001

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
5	Canonical	***MFFTCGPNEAMV	[2]	S-Palmitoylation
34	Canonical	GRVFVLPCIQQIQRI	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Morrow IC, Rea S, Martin S, Prior IA, Prohaska R, Hancock JF, James DE, PartonRG. Flotillin-1/reggie-2 traffics to surface raft domains via a novelgolgi-independent pathway. Identification of a novel membrane targeting domainand a role for palmitoylation. J Biol Chem. 2002 Dec 13;277(50):48834-41. Epub2002 Oct 4.[PMID:12370178]
[2] Predicted from GPS-Lipid

Functional Description

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Sequence Annotation

Modified residue: 19 19 Phosphoserine.
Modified residue: 385 385 Phosphoserine.

Protein Length

427 AA.

Protein Sequence
(Canonical)

MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG  60
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI  120
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE  180
AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL  240
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA  300
EKSQLIMQAE AEAASVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK  360
LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI LTRLPESVER LTGVSISQVN  420
HKPLRTA                                                            427

FASTA
(Canonical)

>LipidDB-9606-00685|O75955
MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHG
VPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEI
YKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGE
AEAKRDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQL
QVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEA
EKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEK
LPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILTRLPESVERLTGVSISQVN
HKPLRTA

Gene Ontology

GO:0005901; C:caveola; TAS:ProtInc
GO:0034451; C:centriolar satellite; IDA:BHF-UCL
GO:0005768; C:endosome; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0016600; C:flotillin complex; IEA:Ensembl
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0016021; C:integral component of membrane; TAS:ProtInc
GO:0005765; C:lysosomal membrane; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0045121; C:membrane raft; IDA:BHF-UCL
GO:0005815; C:microtubule organizing center; IDA:BHF-UCL
GO:0042383; C:sarcolemma; IEA:Ensembl
GO:0002020; F:protease binding; IPI:UniProtKB
GO:0007409; P:axonogenesis; IEA:Ensembl
GO:0090002; P:establishment of protein localization to plasma membrane; IMP:UniProtKB
GO:0022617; P:extracellular matrix disassembly; IMP:UniProt
GO:0035023; P:regulation of Rho protein signal transduction; IEA:Ensembl

Interpro

InterPro; IPR001107; Band_7
InterPro; IPR027705; Flotillin_fam

Pfam

Pfam; PF01145; Band_7;

SMART

SMART; SM00244; PHB;

PROSITE

PRINTS