LipidDB ID

LipidDB-9606-00677

Entry Name

UniProt Accession

Q9Y6E0; O14840; Q5JV92;

Theoretical PI

5.49

Molecular Weight

49307.97

Genbank Protein ID

AAB82560.1; AAD42039.1; CAI13114.1; CAI13114.1; CAI39453.1; CAI39453.1; EAX08986.1; AAH35578.1;

Genbank Nucleotide ID

AF024636; AF083420; AL356423; AL137249; AL137249; AL356423; CH471085; BC035578;

Protein Name

Serine/threonine-protein kinase 24 12 kDa subunit

Protein Synonyms/Alias

2.7.11.1; Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3; Mammalian STE20-like protein kinase 3 N-terminal; MST3/N; Mammalian STE20-like protein kinase 3 C-terminal; MST3/C;

Gene Name

STK24

Gene Synonyms/Alias

MST3; STK3;

Created Date

21-FEB-2001

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Martin DD, Vilas GL, Prescher JA, Rajaiah G, Falck JR, Bertozzi CR, BerthiaumeLG. Rapid detection, discovery, and identification of post-translationallymyristoylated proteins during apoptosis using a bio-orthogonal azidomyristateanalog. FASEB J. 2008 Mar;22(3):797-806. Epub 2007 Oct 10.[PMID:17932026]

Functional Description

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Sequence Annotation

Domain: 36 286 Protein kinase.
Nucleotide-binding: 42 50 ATP.
Nucleotide-binding: 112 114 ATP.
Region: 335 386 Nuclear export signal (NES).
Motif: 278 292 Bipartite nuclear localization signal.
Active site: 156 156 Proton acceptor.
Metal binding site: 161 161 Magnesium.
Metal binding site: 174 174 Magnesium.
Binding site: 65 65 ATP.
Functional site: 325 326 Cleavage; by caspase-3, caspase-7 andcaspase-8.
Modified residue: 18 18 Phosphothreonine; by PKA.
Modified residue: 190 190 Phosphothreonine; by autocatalysis.
Modified residue: 320 320 Phosphoserine.

Protein Length

443 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005730; C:nucleolus; IDA:HPA
GO:0005654; C:nucleoplasm; TAS:Reactome
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0004672; F:protein kinase activity; TAS:ProtInc
GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB
GO:0006915; P:apoptotic process; TAS:Reactome
GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome
GO:0097194; P:execution phase of apoptosis; IMP:UniProtKB
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IMP:UniProtKB
GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB
GO:0006468; P:protein phosphorylation; IDA:UniProtKB
GO:0048679; P:regulation of axon regeneration; IMP:UniProtKB
GO:0007165; P:signal transduction; TAS:ProtInc

Interpro

InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR002290; Ser/Thr_dual-sp_kinase

Pfam

Pfam; PF00069; Pkinase;

SMART

SMART; SM00220; S_TKc;

PROSITE

PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;

PRINTS