LipidDB ID

LipidDB-9606-00675

Entry Name

UniProt Accession

P20336; A8K0J4; Q9NYE1;

Theoretical PI

4.85

Molecular Weight

24983.91

Genbank Protein ID

AAA60242.1; AAD46811.1; AAD46811.1; AAD46811.1; AAD46811.1; AAF67748.1; AAM21079.1; BAF82248.1; AAF67385.1; EAW84672.1; AAH11782.1;

Genbank Nucleotide ID

M28210; AF157809; AF157806; AF157807; AF157808; AF254795; AF498931; AK289559; AC068499; CH471106; BC011782;

Protein Name

Ras-related protein Rab-3A

Protein Synonyms/Alias

Gene Name

RAB3A

Gene Synonyms/Alias

Created Date

01-FEB-1991

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyltransferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci U S A. 1994 Dec6;91(25):11963-7.[PMID:7991565]
[2] Khosravi-Far R, Lutz RJ, Cox AD, Conroy L, Bourne JR, Sinensky M, Balch WE,Buss JE, Der CJ. Isoprenoid modification of rab proteins terminating in CC or CXCmotifs. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6264-8.[PMID:1648736]

Functional Description

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Sequence Annotation

Nucleotide-binding: 29 36 GTP.
Nucleotide-binding: 48 54 GTP.
Nucleotide-binding: 77 81 GTP.
Nucleotide-binding: 135 138 GTP.
Motif: 51 59 Effector region.
Modified residue: 220 220 Cysteine methyl ester.

Protein Length

220 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0001669; C:acrosomal vesicle; IEA:Ensembl
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL
GO:0060201; C:clathrin-sculpted acetylcholine transport vesicle membrane; TAS:Reactome
GO:0061202; C:clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; TAS:Reactome
GO:0060203; C:clathrin-sculpted glutamate transport vesicle membrane; TAS:Reactome
GO:0070083; C:clathrin-sculpted monoamine transport vesicle membrane; TAS:Reactome
GO:0005829; C:cytosol; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0043234; C:protein complex; IEA:Ensembl
GO:0008021; C:synaptic vesicle; ISS:ParkinsonsUK-UCL
GO:0043195; C:terminal bouton; ISS:ParkinsonsUK-UCL
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0001671; F:ATPase activator activity; IEA:Ensembl
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0031489; F:myosin V binding; IPI:UniProtKB
GO:0007409; P:axonogenesis; IEA:Ensembl
GO:0045054; P:constitutive secretory pathway; TAS:ParkinsonsUK-UCL
GO:0014047; P:glutamate secretion; TAS:Reactome
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0030324; P:lung development; IEA:Ensembl
GO:0048790; P:maintenance of presynaptic active zone structure; IEA:Ensembl
GO:0007005; P:mitochondrion organization; IEA:Ensembl
GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl
GO:0007269; P:neurotransmitter secretion; TAS:Reactome
GO:0045921; P:positive regulation of exocytosis; TAS:ParkinsonsUK-UCL
GO:0009791; P:post-embryonic development; IEA:Ensembl
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0048172; P:regulation of short-term neuronal synaptic plasticity; ISS:ParkinsonsUK-UCL
GO:0031630; P:regulation of synaptic vesicle fusion to presynaptic membrane; ISS:ParkinsonsUK-UCL
GO:0003016; P:respiratory system process; IEA:Ensembl
GO:0051602; P:response to electrical stimulus; IEA:Ensembl
GO:0050975; P:sensory perception of touch; IEA:Ensembl
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0016079; P:synaptic vesicle exocytosis; ISS:ParkinsonsUK-UCL
GO:0016188; P:synaptic vesicle maturation; IEA:Ensembl
GO:0036465; P:synaptic vesicle recycling; ISS:ParkinsonsUK-UCL

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;