LipidDB ID

LipidDB-9606-00673

Entry Name

UniProt Accession

P20339; B4DJA5; Q6FI44;

Theoretical PI

8.32

Molecular Weight

23658.68

Genbank Protein ID

AAA60245.1; AAO15677.1; AAM21084.1; BAG58767.1; BAG35504.1; CAG38731.1; EAW64301.1; AAH01267.1; AAH18288.1;

Genbank Nucleotide ID

M28215; AF464088; AF498936; AK295992; AK312618; CR536492; AC097635; CH471055; BC001267; BC018288;

Protein Name

Ras-related protein Rab-5A

Protein Synonyms/Alias

Gene Name

RAB5A

Gene Synonyms/Alias

RAB5;

Created Date

01-FEB-1991

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyltransferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci U S A. 1994 Dec6;91(25):11963-7.[PMID:7991565]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.

Sequence Annotation

Nucleotide-binding: 27 35 GTP.
Nucleotide-binding: 46 52 GTP.
Nucleotide-binding: 75 79 GTP.
Nucleotide-binding: 133 136 GTP.
Nucleotide-binding: 163 165 GTP.
Motif: 49 57 Effector region.

Protein Length

215 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0015629; C:actin cytoskeleton; IEA:Ensembl
GO:0030424; C:axon; ISS:ParkinsonsUK-UCL
GO:0043679; C:axon terminus; ISS:ParkinsonsUK-UCL
GO:0005737; C:cytoplasm; IDA:MGI
GO:0098559; C:cytoplasmic side of early endosome membrane; IMP:UniProtKB
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0030425; C:dendrite; ISS:ParkinsonsUK-UCL
GO:0005769; C:early endosome; IDA:UniProtKB
GO:0005768; C:endosome; ISS:ParkinsonsUK-UCL
GO:0010008; C:endosome membrane; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0043025; C:neuronal cell body; ISS:ParkinsonsUK-UCL
GO:0045335; C:phagocytic vesicle; IEA:Ensembl
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0001726; C:ruffle; IEA:Ensembl
GO:0036477; C:somatodendritic compartment; IDA:ParkinsonsUK-UCL
GO:0008021; C:synaptic vesicle; ISS:ParkinsonsUK-UCL
GO:0043195; C:terminal bouton; IDA:ParkinsonsUK-UCL
GO:0019003; F:GDP binding; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW
GO:0045022; P:early endosome to late endosome transport; IMP:UniProtKB
GO:0006897; P:endocytosis; IDA:UniProtKB
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0007399; P:nervous system development; IEA:UniProtKB-KW
GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:2000286; P:receptor internalization involved in canonical Wnt signaling pathway; IMP:BHF-UCL
GO:0051036; P:regulation of endosome size; IMP:UniProtKB
GO:0051489; P:regulation of filopodium assembly; IDA:UniProtKB
GO:2000300; P:regulation of synaptic vesicle exocytosis; IMP:ParkinsonsUK-UCL
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;