LipidDB-9606-00669

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00669

Entry Name

TRFR_HUMAN

UniProt Accession

P34981; Q2M339;

Theoretical PI

8.62

Molecular Weight

45084.9

Genbank Protein ID

BAA04120.1; CAA52965.1; CAA50979.1; AAB32222.1; AAB32222.1; BAA12796.1; AAR84356.1; AAI05046.1; AAI13361.1; CAA09746.1;

Genbank Nucleotide ID

D16845; X75071; X72089; S75283; S75281; D85376; AY493373; BC105045; BC113360; AJ011701;

Protein Name

Thyrotropin-releasing hormone receptor

Protein Synonyms/Alias

TRH-R; Thyroliberin receptor;

Gene Name

TRHR

Gene Synonyms/Alias

Created Date

01-FEB-1994

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
335	Canonical	RAAFRKLCNCKQKPT	[1]	S-Palmitoylation
337	Canonical	AFRKLCNCKQKPTEK	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Du D, Raaka BM, Grimberg H, Lupu-Meiri M, Oron Y, Gershengorn MC. Carboxyltail cysteine mutants of the thyrotropin-releasing hormone receptor type 1exhibit constitutive signaling: role of palmitoylation. Mol Pharmacol. 2005Jul;68(1):204-9. Epub 2005 Apr 15.[PMID:15833733]

Functional Description

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Sequence Annotation

Topological domain: 1 28 Extracellular.
Transmembrane: 29 51 Helical; Name=1.
Topological domain: 52 61 Cytoplasmic.
Transmembrane: 62 83 Helical; Name=2.
Topological domain: 84 99 Extracellular.
Transmembrane: 100 121 Helical; Name=3.
Topological domain: 122 144 Cytoplasmic.
Transmembrane: 145 168 Helical; Name=4.
Topological domain: 169 193 Extracellular.
Transmembrane: 194 215 Helical; Name=5.
Topological domain: 216 266 Cytoplasmic.
Transmembrane: 267 288 Helical; Name=6.
Topological domain: 289 296 Extracellular.
Transmembrane: 297 319 Helical; Name=7.
Topological domain: 320 398 Cytoplasmic.

Protein Length

398 AA.

Protein Sequence
(Canonical)

MENETVSELN QTQLQPRAVV ALEYQVVTIL LVLIICGLGI VGNIMVVLVV MRTKHMRTPT  60
NCYLVSLAVA DLMVLVAAGL PNITDSIYGS WVYGYVGCLC ITYLQYLGIN ASSCSITAFT  120
IERYIAICHP IKAQFLCTFS RAKKIIIFVW AFTSLYCMLW FFLLDLNIST YKDAIVISCG  180
YKISRNYYSP IYLMDFGVFY VVPMILATVL YGFIARILFL NPIPSDPKEN SKTWKNDSTH  240
QNTNLNVNTS NRCFNSTVSS RKQVTKMLAV VVILFALLWM PYRTLVVVNS FLSSPFQENW  300
FLLFCRICIY LNSAINPVIY NLMSQKFRAA FRKLCNCKQK PTEKPANYSV ALNYSVIKES  360
DHFSTELDDI TVTDTYLSAT KVSFDDTCLA SEVSFSQS                          398

FASTA
(Canonical)

>LipidDB-9606-00669|P34981
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS

Gene Ontology

GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004997; F:thyrotropin-releasing hormone receptor activity; TAS:ProtInc
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc

Interpro

InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR002120; TRH_rcpt_1

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR00751; THYROLIBRINR;
PRINTS; PR01846; TRHRFAMILY;