Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00664
Entry Name
UniProt Accession
Theoretical PI
5.34
Molecular Weight
56598.34
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Neutral amino acid transporter B(0)
Protein Synonyms/Alias
ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5;
Gene Name
SLC1A5
Gene Synonyms/Alias
ASCT2; M7V1; RDR; RDRC;
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
308
Canonical
RLGKYILCCLLGHAI
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).
Sequence Annotation
Topological domain: 1 52 Cytoplasmic.
Transmembrane: 53 73 Helical.
Transmembrane: 99 119 Helical.
Transmembrane: 133 153 Helical.
Topological domain: 154 224 Extracellular.
Transmembrane: 225 245 Helical.
Transmembrane: 266 286 Helical.
Transmembrane: 306 326 Helical.
Transmembrane: 336 356 Helical.
Transmembrane: 377 397 Helical.
Transmembrane: 399 419 Helical.
Transmembrane: 426 446 Helical.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 493 493 Phosphoserine.
Modified residue: 503 503 Phosphoserine.
Modified residue: 535 535 Phosphoserine.
Protein Length
541 AA.
Protein Sequence
(Canonical)
MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR ANLLVLLTVV  60
AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL RMIILPLVVC SLIGGAASLD  120
PGALGRLGAW ALLFFLVTTL LASALGVGLA LALQPGAASA AINASVGAAG SAENAPSKEV  180
LDSFLDLARN IFPSNLVSAA FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV  240
FGVALRKLGP EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA  300
RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT SSSSATLPLM  360
MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF IAQLSQQSLD FVKIITILVT  420
ATASSVGAAG IPAGGVLTLA IILEAVNLPV DHISLILAVD WLVDRSCTVL NVEGDALGAG  480
LLQNYVDRTE SRSTEPELIQ VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV  540
M                                                                  541
FASTA
(Canonical)
>LipidDB-9606-00664|Q15758
MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVV
AVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLD
PGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEV
LDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIV
FGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFA
RLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLM
MKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVT
ATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAG
LLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESV
M
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:HPA
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0015186; F:L-glutamine transmembrane transporter activity; TAS:BHF-UCL
GO:0015194; F:L-serine transmembrane transporter activity; IEA:Ensembl
GO:0015175; F:neutral amino acid transmembrane transporter activity; TAS:ProtInc
GO:0004872; F:receptor activity; TAS:ProtInc
GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro
GO:0001618; F:virus receptor activity; IEA:UniProtKB-KW
GO:0006865; P:amino acid transport; TAS:Reactome
GO:0006860; P:extracellular amino acid transport; IEA:Ensembl
GO:0006868; P:glutamine transport; TAS:BHF-UCL
GO:0006811; P:ion transport; TAS:Reactome
GO:0015804; P:neutral amino acid transport; TAS:ProtInc
GO:0055085; P:transmembrane transport; TAS:Reactome
Interpro
InterPro; IPR001991; Na-dicarboxylate_symporter
InterPro; IPR018107; Na-dicarboxylate_symporter_CS
Pfam
Pfam; PF00375; SDF;
SMART
PROSITE
PROSITE; PS00713; NA_DICARBOXYL_SYMP_1;
PROSITE; PS00714; NA_DICARBOXYL_SYMP_2;
PRINTS
PRINTS; PR00173; EDTRNSPORT;