LipidDB ID

LipidDB-9606-00656

Entry Name

UniProt Accession

P43220; Q2M229; Q99669;

Theoretical PI

8.49

Molecular Weight

53025.8

Genbank Protein ID

AAA03614.1; AAA62471.1; AAC50050.1; AAA17021.1; AAA63787.1; BAC05908.1; AAR05444.1; CAB71177.1; AAI12127.1; AAI13494.1; AAB64013.1;

Genbank Nucleotide ID

U01104; U01157; U01156; L23503; U10037; AB065685; AY439112; AL035690; BC112126; BC113493; U66062;

Protein Name

Glucagon-like peptide 1 receptor

Protein Synonyms/Alias

GLP-1 receptor; GLP-1-R; GLP-1R;

Gene Name

GLP1R

Gene Synonyms/Alias

Created Date

01-NOV-1995

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Vázquez P, Roncero I, Blázquez E, Alvarez E. Substitution of the cysteine 438 residue in the cytoplasmic tail of the glucagon-like peptide-1 receptor alterssignal transduction activity. J Endocrinol. 2005 Apr;185(1):35-44.[PMID:15817825]

Functional Description

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Sequence Annotation

Topological domain: 24 139 Extracellular.
Transmembrane: 140 164 Helical; Name=1.
Topological domain: 165 176 Cytoplasmic.
Transmembrane: 177 201 Helical; Name=2.
Topological domain: 202 227 Extracellular.
Transmembrane: 228 251 Helical; Name=3.
Topological domain: 252 265 Cytoplasmic.
Transmembrane: 266 287 Helical; Name=4.
Topological domain: 288 305 Extracellular.
Transmembrane: 306 328 Helical; Name=5.
Topological domain: 329 352 Cytoplasmic.
Transmembrane: 353 371 Helical; Name=6.
Topological domain: 372 383 Extracellular.
Transmembrane: 384 404 Helical; Name=7.
Topological domain: 405 463 Cytoplasmic.
Modified residue: 341 341 ADP-ribosylcysteine.
Modified residue: 348 348 ADP-ribosylarginine.

Protein Length

463 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016021; C:integral component of membrane; TAS:ProtInc
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004967; F:glucagon receptor activity; IEA:InterPro
GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc
GO:0007190; P:activation of adenylate cyclase activity; TAS:ProtInc
GO:0019933; P:cAMP-mediated signaling; IDA:UniProtKB
GO:0006112; P:energy reserve metabolic process; TAS:Reactome
GO:0007611; P:learning or memory; IEA:Ensembl
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB
GO:0008016; P:regulation of heart contraction; IEA:Ensembl
GO:0050796; P:regulation of insulin secretion; TAS:Reactome
GO:0006950; P:response to stress; IEA:Ensembl
GO:0044281; P:small molecule metabolic process; TAS:Reactome

Interpro

InterPro; IPR017981; GPCR_2-like
InterPro; IPR001879; GPCR_2_extracellular_dom
InterPro; IPR003290; GPCR_2_GLP1/glucagon_rcpt
InterPro; IPR003292; GPCR_2_GLP1_rcpt
InterPro; IPR000832; GPCR_2_secretin-like
InterPro; IPR017983; GPCR_2_secretin-like_CS

Pfam

Pfam; PF00002; 7tm_2;
Pfam; PF02793; HRM;

SMART

SMART; SM00008; HormR;

PROSITE

PROSITE; PS00649; G_PROTEIN_RECEP_F2_1;
PROSITE; PS00650; G_PROTEIN_RECEP_F2_2;
PROSITE; PS50227; G_PROTEIN_RECEP_F2_3;
PROSITE; PS50261; G_PROTEIN_RECEP_F2_4;

PRINTS

PRINTS; PR01353; GLUCAGNFAMLY;
PRINTS; PR01355; GLUCAGNLIKER;
PRINTS; PR00249; GPCRSECRETIN;