LipidDB ID

LipidDB-9606-00653

Entry Name

UniProt Accession

P21453; D3DT66; Q9BYY4; Q9NYN8;

Theoretical PI

9.59

Molecular Weight

42810.79

Genbank Protein ID

AAA52336.1; AAC51905.1; AAF43420.1; BAG35395.1; CAG46585.1; CAG47065.1; CAI21861.1; EAW72927.1; EAW72928.1; AAH18650.1;

Genbank Nucleotide ID

M31210; AF022137; AF233365; AK312493; CR541786; CR542269; AL109741; CH471097; CH471097; BC018650;

Protein Name

Sphingosine 1-phosphate receptor 1

Protein Synonyms/Alias

S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD363;

Gene Name

S1PR1

Gene Synonyms/Alias

CHEDG1; EDG1;

Created Date

01-MAY-1991

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Ohno Y, Ito A, Ogata R, Hiraga Y, Igarashi Y, Kihara A. Palmitoylation of the sphingosine 1-phosphate receptor S1P is involved in its signaling functions andinternalization. Genes Cells. 2009 Aug;14(8):911-23. doi:10.1111/j.1365-2443.2009.01319.x. Epub 2009 Jul 10.[PMID:19619245]

Functional Description

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3- phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Sequence Annotation

Topological domain: 2 46 Extracellular.
Transmembrane: 47 68 Helical; Name=1.
Topological domain: 69 82 Cytoplasmic.
Transmembrane: 83 104 Helical; Name=2.
Topological domain: 105 116 Extracellular.
Transmembrane: 117 138 Helical; Name=3.
Topological domain: 139 160 Cytoplasmic.
Transmembrane: 161 182 Helical; Name=4.
Topological domain: 183 196 Extracellular.
Transmembrane: 197 224 Helical; Name=5.
Topological domain: 225 257 Cytoplasmic.
Transmembrane: 258 278 Helical; Name=6.
Topological domain: 279 289 Extracellular.
Transmembrane: 290 310 Helical; Name=7.
Topological domain: 311 382 Cytoplasmic.
Region: 120 121 Sphingosine 1-phosphate binding.
Region: 265 269 Sphingosine 1-phosphate binding.
Modified residue: 10 10 N6-acetyllysine.
Modified residue: 236 236 Phosphothreonine; by PKB/AKT1.
Modified residue: 353 353 Phosphoserine.

Protein Length

382 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0031226; C:intrinsic component of plasma membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc
GO:0001664; F:G-protein coupled receptor binding; IPI:UniProtKB
GO:0046625; F:sphingolipid binding; IEA:Ensembl
GO:0038036; F:sphingosine-1-phosphate receptor activity; IDA:UniProtKB
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB
GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Ensembl
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW
GO:0001955; P:blood vessel maturation; ISS:UniProtKB
GO:0007420; P:brain development; IEA:Ensembl
GO:0003245; P:cardiac muscle tissue growth involved in heart morphogenesis; ISS:UniProtKB
GO:0007155; P:cell adhesion; TAS:ProtInc
GO:0016477; P:cell migration; ISS:UniProtKB
GO:0006935; P:chemotaxis; ISS:UniProtKB
GO:0045446; P:endothelial cell differentiation; IEA:Ensembl
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0061384; P:heart trabecula morphogenesis; ISS:UniProtKB
GO:0030032; P:lamellipodium assembly; ISS:UniProtKB
GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl
GO:0030182; P:neuron differentiation; IEA:Ensembl
GO:0030335; P:positive regulation of cell migration; IEA:Ensembl
GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Ensembl
GO:0050927; P:positive regulation of positive chemotaxis; IEA:Ensembl
GO:0032320; P:positive regulation of Ras GTPase activity; IEA:Ensembl
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0030500; P:regulation of bone mineralization; ISS:UniProtKB
GO:0045124; P:regulation of bone resorption; ISS:UniProtKB
GO:0030155; P:regulation of cell adhesion; IEA:Ensembl
GO:0003376; P:sphingosine-1-phosphate signaling pathway; IDA:UniProtKB
GO:0072678; P:T cell migration; ISS:UniProtKB
GO:0019226; P:transmission of nerve impulse; IEA:Ensembl

Interpro

InterPro; IPR000987; EDG1_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR004061; S1P_rcpt

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00642; EDG1RECEPTOR;
PRINTS; PR00237; GPCRRHODOPSN;
PRINTS; PR01523; S1PRECEPTOR;