Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00634
Entry Name
UniProt Accession
Theoretical PI
8.41
Molecular Weight
149526.77
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Multidrug resistance-associated protein 4
Protein Synonyms/Alias
ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B;
Gene Name
ABCC4
Gene Synonyms/Alias
MRP4;
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
171
Canonical
MRLRVAMCHMIYRKA
[1]
S-Palmitoylation
511
Canonical
YEKVIKACALKKDLQ
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
May be an organic anion pump relevant to cellular detoxification.
Sequence Annotation
Transmembrane: 93 113 Helical.
Transmembrane: 136 156 Helical.
Transmembrane: 207 227 Helical.
Transmembrane: 228 248 Helical.
Transmembrane: 328 348 Helical.
Transmembrane: 351 371 Helical.
Transmembrane: 440 460 Helical.
Transmembrane: 710 730 Helical.
Transmembrane: 771 791 Helical.
Transmembrane: 836 856 Helical.
Transmembrane: 858 878 Helical.
Transmembrane: 954 974 Helical.
Transmembrane: 977 997 Helical.
Transmembrane: 1038 1058 Helical.
Domain: 92 377 ABC transmembrane type-1 1.
Domain: 410 633 ABC transporter 1.
Domain: 714 1005 ABC transmembrane type-1 2.
Domain: 1041 1274 ABC transporter 2.
Nucleotide-binding: 445 452 ATP 1.
Nucleotide-binding: 1075 1082 ATP 2.
Motif: 1322 1325 PDZ-binding.
Modified residue: 646 646 Phosphothreonine.
Protein Length
1325 AA.
Protein Sequence
(Canonical)
MLPVYQEVKP NPLQDANLCS RVFFWWLNPL FKIGHKRRLE EDDMYSVLPE DRSQHLGEEL  60
QGFWDKEVLR AENDAQKPSL TRAIIKCYWK SYLVLGIFTL IEESAKVIQP IFLGKIINYF  120
ENYDPMDSVA LNTAYAYATV LTFCTLILAI LHHLYFYHVQ CAGMRLRVAM CHMIYRKALR  180
LSNMAMGKTT TGQIVNLLSN DVNKFDQVTV FLHFLWAGPL QAIAVTALLW MEIGISCLAG  240
MAVLIILLPL QSCFGKLFSS LRSKTATFTD ARIRTMNEVI TGIRIIKMYA WEKSFSNLIT  300
NLRKKEISKI LRSSCLRGMN LASFFSASKI IVFVTFTTYV LLGSVITASR VFVAVTLYGA  360
VRLTVTLFFP SAIERVSEAI VSIRRIQTFL LLDEISQRNR QLPSDGKKMV HVQDFTAFWD  420
KASETPTLQG LSFTVRPGEL LAVVGPVGAG KSSLLSAVLG ELAPSHGLVS VHGRIAYVSQ  480
QPWVFSGTLR SNILFGKKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGTTLSGGQK  540
ARVNLARAVY QDADIYLLDD PLSAVDAEVS RHLFELCICQ ILHEKITILV THQLQYLKAA  600
SQILILKDGK MVQKGTYTEF LKSGIDFGSL LKKDNEESEQ PPVPGTPTLR NRTFSESSVW  660
SQQSSRPSLK DGALESQDTE NVPVTLSEEN RSEGKVGFQA YKNYFRAGAH WIVFIFLILL  720
NTAAQVAYVL QDWWLSYWAN KQSMLNVTVN GGGNVTEKLD LNWYLGIYSG LTVATVLFGI  780
ARSLLVFYVL VNSSQTLHNK MFESILKAPV LFFDRNPIGR ILNRFSKDIG HLDDLLPLTF  840
LDFIQTLLQV VGVVSVAVAV IPWIAIPLVP LGIIFIFLRR YFLETSRDVK RLESTTRSPV  900
FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV RLDAICAMFV  960
IIVAFGSLIL AKTLDAGQVG LALSYALTLM GMFQWCVRQS AEVENMMISV ERVIEYTDLE  1020
KEAPWEYQKR PPPAWPHEGV IIFDNVNFMY SPGGPLVLKH LTALIKSQEK VGIVGRTGAG  1080
KSSLISALFR LSEPEGKIWI DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE  1140
HTDEELWNAL QEVQLKETIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILRKNQILII  1200
DEATANVDPR TDELIQKKIR EKFAHCTVLT IAHRLNTIID SDKIMVLDSG RLKEYDEPYV  1260
LLQNKESLFY KMVQQLGKAE AAALTETAKQ VYFKRNYPHI GHTDHMVTNT SNGQPSTLTI  1320
FETAL                                                              1325
FASTA
(Canonical)
>LipidDB-9606-00634|O15439
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
LDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPV
FSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFV
IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE
KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAG
KSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNE
HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILII
DEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYV
LLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI
FETAL
Gene Ontology
GO:0016323; C:basolateral plasma membrane; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:MGI
GO:0031088; C:platelet dense granule membrane; IDA:MGI
GO:0016404; F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAS:UniProtKB
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0055114; P:oxidation-reduction process; NAS:GOC
GO:0030168; P:platelet activation; TAS:Reactome
GO:0002576; P:platelet degranulation; TAS:Reactome
GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl
GO:0042493; P:response to drug; IEA:Ensembl
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl
GO:0010243; P:response to organonitrogen compound; IEA:Ensembl
GO:0055085; P:transmembrane transport; TAS:Reactome
Interpro
InterPro; IPR003593; AAA+_ATPase
InterPro; IPR011527; ABC1_TM_dom
InterPro; IPR003439; ABC_transporter-like
InterPro; IPR017871; ABC_transporter_CS
InterPro; IPR001140; ABC_transptr_TM_dom
InterPro; IPR027417; P-loop_NTPase
Pfam
Pfam; PF00664; ABC_membrane;
Pfam; PF00005; ABC_tran;
SMART
SMART; SM00382; AAA;
PROSITE
PROSITE; PS50929; ABC_TM1F;
PROSITE; PS00211; ABC_TRANSPORTER_1;
PROSITE; PS50893; ABC_TRANSPORTER_2;
PRINTS