LipidDB ID

LipidDB-9606-00629

Entry Name

UniProt Accession

P63241; A8K9A0; D3DTP2; P10159; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2;

Theoretical PI

5.07

Molecular Weight

16832.25

Genbank Protein ID

AAA58453.1; AAD14095.1; AAA86989.1; AAN17514.1; AAN17515.1; AAN17516.1; AAN17518.1; BAF85304.1; EAW90219.1; EAW90220.1; EAW90221.1; EAW90222.1; AAH00751.1; AAH01832.1; AAH30160.1; AAH80196.1; AAH85015.1; AAI07780.1;

Genbank Nucleotide ID

M23419; S72024; U17969; AY129319; AY129320; AY129321; AY129322; AK292615; CH471108; CH471108; CH471108; CH471108; BC000751; BC001832; BC030160; BC080196; BC085015; BC107779;

Protein Name

Eukaryotic translation initiation factor 5A-1

Protein Synonyms/Alias

eIF-5A-1; eIF-5A1; Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D;

Gene Name

EIF5A

Gene Synonyms/Alias

Created Date

11-OCT-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.

Sequence Annotation

Region: 20 90 DOHH-binding.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 47 47 N6-acetyllysine.
Modified residue: 50 50 Hypusine.
Modified residue: 121 121 N6-acetyllysine.

Protein Length

154 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005642; C:annulate lamellae; IDA:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005643; C:nuclear pore; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB
GO:0047485; F:protein N-terminus binding; IPI:UniProtKB
GO:0043022; F:ribosome binding; IEA:InterPro
GO:0003723; F:RNA binding; IDA:UniProtKB
GO:0003746; F:translation elongation factor activity; ISS:UniProtKB
GO:0017070; F:U6 snRNA binding; IDA:UniProtKB
GO:0006915; P:apoptotic process; IDA:UniProtKB
GO:0044267; P:cellular protein metabolic process; TAS:Reactome
GO:0006406; P:mRNA export from nucleus; IMP:UniProtKB
GO:0006913; P:nucleocytoplasmic transport; IMP:UniProtKB
GO:0008612; P:peptidyl-lysine modification to peptidyl-hypusine; TAS:Reactome
GO:0008284; P:positive regulation of cell proliferation; IGI:UniProtKB
GO:0045901; P:positive regulation of translational elongation; ISS:UniProtKB
GO:0045905; P:positive regulation of translational termination; IEA:InterPro
GO:0043687; P:post-translational protein modification; TAS:Reactome
GO:0006611; P:protein export from nucleus; IMP:UniProtKB
GO:0006452; P:translational frameshifting; IEA:InterPro

Interpro

InterPro; IPR012340; NA-bd_OB-fold
InterPro; IPR014722; Rib_L2_dom2
InterPro; IPR019769; Trans_elong_IF5A_hypusine_site
InterPro; IPR001884; Transl_elong_IF5A
InterPro; IPR020189; Transl_elong_IF5A_C
InterPro; IPR008991; Translation_prot_SH3-like

Pfam

Pfam; PF01287; eIF-5a;

SMART

PROSITE

PROSITE; PS00302; IF5A_HYPUSINE;

PRINTS