Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00626
Entry Name
UniProt Accession
Theoretical PI
5.35
Molecular Weight
24607.85
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Ras-related protein Rab-27B
Protein Synonyms/Alias
C25KG;
Gene Name
RAB27B
Gene Synonyms/Alias
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
216
Canonical
EKPPEKKCIC*****
[1]
S-Geranylgeranylation
218
Canonical
PPEKKCIC*******
[1]
S-Geranylgeranylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van den Broecke R, LambertJ, Van Belle S, Cocquyt V, Gespach C, Bracke M, Seabra MC, Gahl WA, De Wever O,Westbroek W. Effect of the secretory small GTPase Rab27B on breast cancer growth,invasion, and metastasis. J Natl Cancer Inst. 2010 Jun 16;102(12):866-80. doi:10.1093/jnci/djq153. Epub 2010 May 18.[PMID:20484105]
Functional Description
May be involved in targeting uroplakins to urothelial apical membranes.
Sequence Annotation
Nucleotide-binding: 16 24 GTP.
Nucleotide-binding: 74 78 GTP.
Nucleotide-binding: 133 136 GTP.
Nucleotide-binding: 163 165 GTP.
Motif: 38 46 Effector region.
Modified residue: 2 2 N-acetylthreonine.
Modified residue: 218 218 Cysteine methyl ester.
Protein Length
218 AA.
Protein Sequence
(Canonical)
MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR VVYNAQGPNG  60
SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD LTSQQSFLNV RNWMSQLQAN  120
AYCENPDIVL IGNKADLPDQ REVNERQARE LADKYGIPYF ETSAATGQNV EKAVETLLDL  180
IMKRMEQCVE KTQIPDTVNG GNSGNLDGEK PPEKKCIC                          218
FASTA
(Canonical)
>LipidDB-9606-00626|O00194
MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNG
SSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQAN
AYCENPDIVLIGNKADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDL
IMKRMEQCVEKTQIPDTVNGGNSGNLDGEKPPEKKCIC
Gene Ontology
GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005795; C:Golgi stack; IDA:UniProtKB
GO:0032585; C:multivesicular body membrane; IDA:UniProtKB
GO:0030140; C:trans-Golgi network transport vesicle; IDA:UniProtKB
GO:0042589; C:zymogen granule membrane; IEA:Ensembl
GO:0019003; F:GDP binding; IDA:UniProtKB
GO:0005525; F:GTP binding; ISS:UniProtKB
GO:0003924; F:GTPase activity; ISS:UniProtKB
GO:0019904; F:protein domain specific binding; IPI:UniProtKB
GO:0071985; P:multivesicular body sorting pathway; IMP:UniProtKB
GO:0045921; P:positive regulation of exocytosis; IMP:UniProtKB
GO:0015031; P:protein transport; IEA:InterPro
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00175; RAB;
PROSITE
PROSITE; PS51419; RAB;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;