| Tag |
Content |
LipidDB ID |
LipidDB-9606-00622 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
6.07 |
Molecular Weight |
21005.48 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Germinal center-associated signaling and motility protein |
Protein Synonyms/Alias |
Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL; |
Gene Name |
GCSAM |
Gene Synonyms/Alias |
GAL; GCET2; |
Created Date |
31-OCT-2006 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
43 | Canonical | DHHIAEGCFCLPWKK | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Pan Z, Shen Y, Ge B, Du C, McKeithan T, Chan WC. Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapterprotein. Br J Haematol. 2007 Jun;137(6):578-90. Epub 2007 May 9.[ PMID:17489982]
|
Functional Description |
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. |
Sequence Annotation |
Modified residue: 148 148 Phosphotyrosine.
|
Protein Length |
178 AA. |
Protein Sequence
(Canonical) |
MGNSLLRENR RQQNTQEMPW NVRMQSPKQR TSRCWDHHIA EGCFCLPWKK ILIFEKRQDS 60
QNENERMSST PIQDNVDQTY SEELCYTLIN HRVLCTRPSG NSAEEYYENV PCKAERPRES 120
LGGTETEYSL LHMPSTDPRH ARSPEDEYEL LMPHRISSHF LQQPRPLMAP SETQFSHL 178
|
FASTA
(Canonical) |
>LipidDB-9606-00622|Q8N6F7
MGNSLLRENRRQQNTQEMPWNVRMQSPKQRTSRCWDHHIAEGCFCLPWKKILIFEKRQDS
QNENERMSSTPIQDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRES
LGGTETEYSLLHMPSTDPRHARSPEDEYELLMPHRISSHFLQQPRPLMAPSETQFSHL
|
Gene Ontology |
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; IEA:UniProtKB-KW GO:0003779; F:actin binding; IPI:UniProtKB GO:0045159; F:myosin II binding; IPI:UniProtKB GO:0019901; F:protein kinase binding; IPI:UniProtKB GO:2000402; P:negative regulation of lymphocyte migration; IMP:UniProtKB GO:0050855; P:regulation of B cell receptor signaling pathway; IMP:UniProtKB |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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