Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00617
Entry Name
UniProt Accession
Theoretical PI
9.76
Molecular Weight
38704.51
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Cyclin-dependent kinase 5 activator 2
Protein Synonyms/Alias
CDK5 activator 2; Cyclin-dependent kinase 5 regulatory subunit 2; p39; p39I;
Gene Name
CDK5R2
Gene Synonyms/Alias
NCK5AI;
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGTVLSLSP
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Asada A, Yamamoto N, Gohda M, Saito T, Hayashi N, Hisanaga S. Myristoylationof p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. J Neurochem. 2008 Aug;106(3):1325-36. doi:10.1111/j.1471-4159.2008.05500.x. Epub 2008 May 26.[PMID:18507738]
Functional Description
Activator of CDK5/TPKII.
Sequence Annotation
Protein Length
367 AA.
Protein Sequence
(Canonical)
MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPVGKGGKG ESRLKRPSVL  60
ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN RENLLRKGRD PPDGGGTAKP  120
LAVPVPTVPA AAATCEPPSG GSAAAQPPGS GGGKPPPPPP PAPQVAPPVP GGSPRRVIVQ  180
ASTGELLRCL GDFVCRRCYR LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY  240
LLCRESLRGD ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL  300
IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASGGGPPS GGAPAASSAA RDSCAAGTKH  360
WTMNLDR                                                            367
FASTA
(Canonical)
>LipidDB-9606-00617|Q13319
MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVL
ISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKP
LAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQ
ASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY
LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRL
IQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKH
WTMNLDR
Gene Ontology
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:InterPro
GO:0005737; C:cytoplasm; IEA:Ensembl
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0016534; F:cyclin-dependent protein kinase 5 activator activity; IEA:Ensembl
GO:0008289; F:lipid binding; IEA:UniProtKB-KW
GO:0021549; P:cerebellum development; IEA:Ensembl
GO:0021766; P:hippocampus development; IEA:Ensembl
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl
GO:0001764; P:neuron migration; IEA:Ensembl
GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl
GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc
GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl
Interpro
InterPro; IPR004944; CDK5_activator
InterPro; IPR013763; Cyclin-like
Pfam
Pfam; PF03261; CDK5_activator;
SMART
PROSITE
PRINTS