LipidDB-9606-00612

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00612

Entry Name

I5P1_HUMAN

UniProt Accession

Q14642; D3DXI3; Q14640; Q5JSF1;

Theoretical PI

6.58

Molecular Weight

47819.52

Genbank Protein ID

CAA54676.1; CAI39945.1; CAI39945.1; CAI39945.1; CAI14121.1; CAI14121.1; CAI14121.1; CAI40942.1; CAI40942.1; CAI40942.1; EAW61306.1; EAW61307.1; AAH96280.1; CAA83500.1;

Genbank Nucleotide ID

X77567; AL392043; AL356603; AL451069; AL451069; AL392043; AL356603; AL356603; AL451069; AL392043; CH471211; CH471211; BC096280; Z31695;

Protein Name

Type I inositol 1,4,5-trisphosphate 5-phosphatase

Protein Synonyms/Alias

5PTase; 3.1.3.56;

Gene Name

INPP5A

Gene Synonyms/Alias

Created Date

15-JUL-1998

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
409	Canonical	HAHVHKCCVVQ****	[1]	S-Farnesylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] De Smedt F, Boom A, Pesesse X, Schiffmann SN, Erneux C. Post-translationalmodification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation. J Biol Chem. 1996 Apr 26;271(17):10419-24.[PMID:8626616]

Functional Description

Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.

Sequence Annotation

Modified residue: 409 409 Cysteine methyl ester.

Protein Length

412 AA.

Protein Sequence
(Canonical)

MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN  60
YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF  120
DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL  180
VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK  240
SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT  300
ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL  360
VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCCV VQ          412

FASTA
(Canonical)

>LipidDB-9606-00612|Q14642
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN
YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF
DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL
VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK
SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT
ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL
VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016020; C:membrane; NAS:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:UniProtKB-EC
GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC
GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; NAS:UniProtKB
GO:0042731; F:PH domain binding; IPI:BHF-UCL
GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome
GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro
GO:0044281; P:small molecule metabolic process; TAS:Reactome

Interpro

InterPro; IPR005135; Endo/exonuclease/phosphatase
InterPro; IPR000300; IPPc

Pfam

Pfam; PF03372; Exo_endo_phos;

SMART

SMART; SM00128; IPPc;

PROSITE

PRINTS