Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00608
Entry Name
UniProt Accession
Theoretical PI
5.67
Molecular Weight
78410.93
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Nicastrin
Protein Synonyms/Alias
Gene Name
NCSTN
Gene Synonyms/Alias
KIAA0253; UNQ1874/PRO4317;
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
689
Canonical
FSLIVTYCINAKADV
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, ThinakaranG. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem.2009 Jan 16;284(3):1373-84. doi: 10.1074/jbc.M806380200. Epub 2008 Nov 20. PubMedPMID: 19028695; PubMed Central PMCID: PMC2615504.[PMID:19028695]
Functional Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Sequence Annotation
Topological domain: 34 669 Extracellular.
Transmembrane: 670 690 Helical.
Topological domain: 691 709 Cytoplasmic.
Protein Length
709 AA.
Protein Sequence
(Canonical)
MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI  60
GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG  120
LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI  180
FLLEDENETK VIKQCYQDHN LSQNGSAPTF PLCAMQLFSH MHAVISTATC MRRSSIQSTF  240
SINPEIVCDP LSDYNVWSML KPINTTGTLK PDDRVVVAAT RLDSRSFFWN VAPGAESAVA  300
SFVTQLAAAE ALQKAPDVTT LPRNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENVD  360
SFVELGQVAL RTSLELWMHT DPVSQKNESV RNQVEDLLAT LEKSGAGVPA VILRRPNQSQ  420
PLPPSSLQRF LRARNISGVV LADHSGAFHN KYYQSIYDTA ENINVSYPEW LSPEEDLNFV  480
TDTAKALADV ATVLGRALYE LAGGTNFSDT VQADPQTVTR LLYGFLIKAN NSWFQSILRQ  540
DLRSYLGDGP LQHYIAVSSP TNTTYVVQYA LANLTGTVVN LTREQCQDPS KVPSENKDLY  600
EYSWVQGPLH SNETDRLPRC VRSTARLARA LSPAFELSQW SSTEYSTWTE SRWKDIRARI  660
FLIASKELEL ITLTVGFGIL IFSLIVTYCI NAKADVLFIA PREPGAVSY              709
FASTA
(Canonical)
>LipidDB-9606-00608|Q92542
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Gene Ontology
GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; ISS:UniProtKB
GO:0016021; C:integral component of membrane; NAS:UniProtKB
GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB
GO:0005765; C:lysosomal membrane; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004175; F:endopeptidase activity; IEA:Ensembl
GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC
GO:0097190; P:apoptotic signaling pathway; TAS:Reactome
GO:0050435; P:beta-amyloid metabolic process; IEA:Ensembl
GO:0050673; P:epithelial cell proliferation; IEA:Ensembl
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome
GO:0030198; P:extracellular matrix organization; TAS:Reactome
GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB
GO:0031293; P:membrane protein intracellular domain proteolysis; TAS:Reactome
GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0007220; P:Notch receptor processing; TAS:HGNC
GO:0007219; P:Notch signaling pathway; TAS:Reactome
GO:0043065; P:positive regulation of apoptotic process; TAS:Reactome
GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB
GO:0016485; P:protein processing; ISS:UniProtKB
GO:0006508; P:proteolysis; NAS:UniProtKB
GO:0042098; P:T cell proliferation; IEA:Ensembl
Interpro
InterPro; IPR008710; Nicastrin
Pfam
Pfam; PF05450; Nicastrin;
SMART
PROSITE
PRINTS