Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00603
Entry Name
UniProt Accession
Theoretical PI
9.05
Molecular Weight
24381.83
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Regulator of G-protein signaling 2
Protein Synonyms/Alias
RGS2; Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8;
Gene Name
RGS2
Gene Synonyms/Alias
G0S8; GIG31;
Created Date
01-FEB-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
106
Canonical
AFLKSEFCEENIEFW
[1]
S-Palmitoylation
116
Canonical
NIEFWLACEDFKKTK
[1]
S-Palmitoylation
199
Canonical
SEFYQDLCKKPQITT
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Ni J, Qu L, Yang H, Wang M, Huang Y. Palmitoylation and its effect on theGTPase-activating activity and conformation of RGS2. Int J Biochem Cell Biol.2006;38(12):2209-18. Epub 2006 Aug 3.[PMID:16945566]
Functional Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Sequence Annotation
Domain: 83 199 RGS.
Region: 32 66 Necessary for membrane association.
Region: 79 116 Necessary to inhibit protein synthesis.
Protein Length
211 AA.
Protein Sequence
(Canonical)
MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT  60
GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK  120
KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL  180
MENNSYPRFL ESEFYQDLCK KPQITTEPHA T                                 211
FASTA
(Canonical)
>LipidDB-9606-00603|P41220
MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKT
GKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFK
KTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSL
MENNSYPRFLESEFYQDLCKKPQITTEPHAT
Gene Ontology
GO:0005737; C:cytoplasm; IBA:RefGenome
GO:0009898; C:cytoplasmic side of plasma membrane; ISS:BHF-UCL
GO:0005829; C:cytosol; ISS:BHF-UCL
GO:0005739; C:mitochondrion; IEA:UniProtKB-KW
GO:0043005; C:neuron projection; IEA:Ensembl
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IBA:RefGenome
GO:0005516; F:calmodulin binding; TAS:ProtInc
GO:0005096; F:GTPase activator activity; IBA:RefGenome
GO:0050873; P:brown fat cell differentiation; IEA:Ensembl
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0043951; P:negative regulation of cAMP-mediated signaling; IEA:Ensembl
GO:0010614; P:negative regulation of cardiac muscle hypertrophy; ISS:BHF-UCL
GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; ISS:BHF-UCL
GO:0043407; P:negative regulation of MAP kinase activity; ISS:BHF-UCL
GO:0010519; P:negative regulation of phospholipase activity; ISS:BHF-UCL
GO:0060452; P:positive regulation of cardiac muscle contraction; ISS:BHF-UCL
GO:0031116; P:positive regulation of microtubule polymerization; IEA:Ensembl
GO:0071877; P:regulation of adrenergic receptor signaling pathway; ISS:BHF-UCL
GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc
GO:0006417; P:regulation of translation; IEA:UniProtKB-KW
GO:0055119; P:relaxation of cardiac muscle; ISS:BHF-UCL
GO:0060087; P:relaxation of vascular smooth muscle; IEA:Ensembl
GO:0007283; P:spermatogenesis; IEA:Ensembl
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro
Interpro
InterPro; IPR024066; Regulat_G_prot_signal_dom1
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom
Pfam
Pfam; PF00615; RGS;
SMART
SMART; SM00315; RGS;
PROSITE
PROSITE; PS50132; RGS;
PRINTS
PRINTS; PR01301; RGSPROTEIN;