| Tag |
Content |
LipidDB ID |
LipidDB-9606-00594 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.04 |
Molecular Weight |
33077.32 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
B-lymphocyte antigen CD20 |
Protein Synonyms/Alias |
B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20; |
Gene Name |
MS4A1 |
Gene Synonyms/Alias |
CD20; |
Created Date |
01-OCT-1989 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
111 | Canonical | TEKNSRKCLVKGKMI | [1] | S-Palmitoylation | 220 | Canonical | ENEWKRTCSRPKSNI | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Ivaldi C, Martin BR, Kieffer-Jaquinod S, Chapel A, Levade T, Garin J, Journet A. Proteomic analysis of S-acylated proteins in human B cells revealspalmitoylation of the immune regulators CD20 and CD23. PLoS One.2012;7(5):e37187. doi: 10.1371/journal.pone.0037187. Epub 2012 May 17. PubMedPMID: 22615937; PubMed Central PMCID: PMC3355122.[ PMID:22615937]
|
Functional Description |
This protein may be involved in the regulation of B-cell activation and proliferation. |
Sequence Annotation |
Topological domain: 1 56 Cytoplasmic.
Transmembrane: 57 78 Helical.
Topological domain: 79 84 Extracellular.
Transmembrane: 85 105 Helical.
Topological domain: 106 120 Cytoplasmic.
Transmembrane: 121 141 Helical.
Topological domain: 142 188 Extracellular.
Transmembrane: 189 209 Helical.
Topological domain: 210 297 Cytoplasmic.
Region: 74 80 Epitope 1.
Region: 146 160 Epitope 2.
Region: 168 175 Epitope 3 (recognized by antibodies,including Rituximab).
|
Protein Length |
297 AA. |
Protein Sequence
(Canonical) |
MTTPRNSVNG TFPAEPMKGP IAMQSGPKPL FRRMSSLVGP TQSFFMRESK TLGAVQIMNG 60
LFHIALGGLL MIPAGIYAPI CVTVWYPLWG GIMYIISGSL LAATEKNSRK CLVKGKMIMN 120
SLSLFAAISG MILSIMDILN IKISHFLKME SLNFIRAHTP YINIYNCEPA NPSEKNSPST 180
QYCYSIQSLF LGILSVMLIF AFFQELVIAG IVENEWKRTC SRPKSNIVLL SAEEKKEQTI 240
EIKEEVVGLT ETSSQPKNEE DIEIIPIQEE EEEETETNFP EPPQDQESSP IENDSSP 297
|
FASTA
(Canonical) |
>LipidDB-9606-00594|P11836
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
|
Gene Ontology |
GO:0009897; C:external side of plasma membrane; IEA:Ensembl GO:0005615; C:extracellular space; IDA:UniProt GO:0070062; C:extracellular vesicular exosome; IDA:UniProt GO:0005887; C:integral component of plasma membrane; NAS:UniProt GO:0023026; F:MHC class II protein complex binding; IDA:UniProt GO:0042100; P:B cell proliferation; NAS:UniProt GO:0006959; P:humoral immune response; NAS:UniProt |
Interpro |
|
Pfam |
|
SMART |
|
PROSITE |
|
PRINTS |
|