LipidDB ID

LipidDB-9606-00587

Entry Name

UniProt Accession

O15498; B4DR94; Q53F01; Q6FGU9; Q6IB15;

Theoretical PI

6.44

Molecular Weight

22417.58

Genbank Protein ID

AAB81131.1; AAP35741.1; BAG61206.1; CAG33270.1; CAG46805.1; BAD97208.1; AAH07319.1;

Genbank Nucleotide ID

U95735; BT007078; AK299158; CR456989; CR542008; AK223488; AC006454; BC007319;

Protein Name

Synaptobrevin homolog YKT6

Protein Synonyms/Alias

2.3.1.-;

Gene Name

YKT6

Gene Synonyms/Alias

Created Date

20-MAR-2007

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Fukasawa M, Varlamov O, Eng WS, Söllner TH, Rothman JE. Localization andactivity of the SNARE Ykt6 determined by its regulatory domain andpalmitoylation. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4815-20. Epub 2004Mar 24.[PMID:15044687]
[2] Veit M. The human SNARE protein Ykt6 mediates its own palmitoylation atC-terminal cysteine residues. Biochem J. 2004 Dec 1;384(Pt 2):233-7.[PMID:15479160]

Functional Description

Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

Sequence Annotation

Domain: 8 126 Longin.
Domain: 138 198 v-SNARE coiled-coil homology.
Modified residue: 195 195 Cysteine methyl ester.

Protein Length

198 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:HPA
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW
GO:0005783; C:endoplasmic reticulum; IDA:HGNC
GO:0005768; C:endosome; IDA:HGNC
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:HGNC
GO:0005887; C:integral component of plasma membrane; IDA:HGNC
GO:0005739; C:mitochondrion; IDA:HPA
GO:0031201; C:SNARE complex; ISS:HGNC
GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IDA:HGNC
GO:0005484; F:SNAP receptor activity; IDA:HGNC
GO:0006888; P:ER to Golgi vesicle-mediated transport; IDA:HGNC
GO:0008152; P:metabolic process; IDA:GOC
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0042147; P:retrograde transport, endosome to Golgi; IDA:HGNC
GO:0006904; P:vesicle docking involved in exocytosis; IDA:HGNC
GO:0006903; P:vesicle targeting; IDA:HGNC

Interpro

InterPro; IPR011012; Longin-like_dom
InterPro; IPR010908; Longin_dom
InterPro; IPR001388; Synaptobrevin

Pfam

Pfam; PF13774; Longin;
Pfam; PF00957; Synaptobrevin;

SMART

PROSITE

PROSITE; PS50859; LONGIN;
PROSITE; PS50892; V_SNARE;

PRINTS