Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00571
Entry Name
UniProt Accession
Theoretical PI
8.02
Molecular Weight
75592.04
Genbank Protein ID
CAA62631.1; BAB13728.2; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28842.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28838.1; AAK28841.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28840.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28839.1; AAL06598.1; BAA95530.1; AAH29158.2; AAC51098.1;
Genbank Nucleotide ID
X91249; AB038161; AJ289137; AJ289138; AJ289139; AJ289140; AJ289141; AJ289142; AJ289143; AJ289144; AJ289145; AJ289146; AJ289147; AJ289148; AJ289149; AJ289150; AJ289151; AF323658; AF323644; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323664; AF323658; AF323640; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323660; AF323663; AF323658; AF323642; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323662; AF323658; AF323643; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323658; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323661; AY048757; AP001746; BC029158; U34919;
Protein Name
ATP-binding cassette sub-family G member 1
Protein Synonyms/Alias
ATP-binding cassette transporter 8; White protein homolog;
Gene Name
ABCG1
Gene Synonyms/Alias
ABC8; WHT1;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
30
Canonical
MTEPKSVCVSVDEVV
[1]
S-Palmitoylation
154
Canonical
GLPRDLRCFRKVSCY
[1]
S-Palmitoylation
315
Canonical
LRDLGLNCPTYHNPA
[1]
S-Palmitoylation
394
Canonical
DSSSMEGCHSFSASC
[1]
S-Palmitoylation
406
Canonical
ASCLTQFCILFKRTF
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Gu HM, Li G, Gao X, Berthiaume LG, Zhang DW. Characterization ofpalmitoylation of ATP binding cassette transporter G1: effect on proteintrafficking and function. Biochim Biophys Acta. 2013 Jun;1831(6):1067-78. doi:10.1016/j.bbalip.2013.01.019. Epub 2013 Feb 4.[PMID:23388354]
Functional Description
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Sequence Annotation
Topological domain: 1 426 Cytoplasmic.
Transmembrane: 427 445 Helical.
Topological domain: 446 456 Extracellular.
Transmembrane: 457 477 Helical.
Topological domain: 478 506 Cytoplasmic.
Transmembrane: 507 525 Helical.
Topological domain: 526 533 Extracellular.
Transmembrane: 534 555 Helical.
Topological domain: 556 567 Cytoplasmic.
Transmembrane: 568 586 Helical.
Topological domain: 587 649 Extracellular.
Transmembrane: 650 669 Helical.
Topological domain: 670 678 Cytoplasmic.
Domain: 77 317 ABC transporter.
Domain: 415 673 ABC transmembrane type-2.
Nucleotide-binding: 118 125 ATP.
Protein Length
678 AA.
Protein Sequence
(Canonical)
MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN GHLKKVDNNL  60
TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL LKGISGKFNS GELVAIMGPS  120
GAGKSTLMNI LAGYRETGMK GAVLINGLPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV  180
SAHLKLQEKD EGRREMVKEI LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF  240
DEPTSGLDSA SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK  300
VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD SDHKRDLGGD  360
AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS CLTQFCILFK RTFLSIMRDS  420
VLTHLRITSH IGIGLLIGLL YLGIGNEAKK VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE  480
MGVFLREHLN YWYSLKAYYL AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL  540
GTMTSLVAQS LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS  600
YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL DFIVLGIFFI  660
SLRLIAYFVL RYKIRAER                                                678
FASTA
(Canonical)
>LipidDB-9606-00571|P45844
MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNL
TEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPS
GAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV
SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFF
DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGK
VCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD
AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDS
VLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE
MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAAL
GTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYIS
YVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI
SLRLIAYFVLRYKIRAER
Gene Ontology
GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005768; C:endosome; ISS:BHF-UCL
GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; IC:UniProtKB
GO:0005739; C:mitochondrion; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0055037; C:recycling endosome; ISS:BHF-UCL
GO:0043531; F:ADP binding; IDA:BHF-UCL
GO:0005524; F:ATP binding; IDA:BHF-UCL
GO:0015485; F:cholesterol binding; IC:BHF-UCL
GO:0017127; F:cholesterol transporter activity; IDA:BHF-UCL
GO:0034437; F:glycoprotein transporter activity; IDA:BHF-UCL
GO:0005543; F:phospholipid binding; IC:BHF-UCL
GO:0005548; F:phospholipid transporter activity; IDA:BHF-UCL
GO:0046983; F:protein dimerization activity; NAS:UniProtKB
GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL
GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL
GO:0034041; F:sterol-transporting ATPase activity; IDA:BHF-UCL
GO:0019534; F:toxin transporter activity; IDA:BHF-UCL
GO:0042987; P:amyloid precursor protein catabolic process; IDA:BHF-UCL
GO:0033344; P:cholesterol efflux; IDA:BHF-UCL
GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL
GO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL
GO:0009720; P:detection of hormone stimulus; NAS:UniProtKB
GO:0034436; P:glycoprotein transport; IDA:BHF-UCL
GO:0034375; P:high-density lipoprotein particle remodeling; ISS:BHF-UCL
GO:0032367; P:intracellular cholesterol transport; IMP:BHF-UCL
GO:0042157; P:lipoprotein metabolic process; TAS:Reactome
GO:0034374; P:low-density lipoprotein particle remodeling; ISS:BHF-UCL
GO:0010887; P:negative regulation of cholesterol storage; TAS:BHF-UCL
GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; TAS:BHF-UCL
GO:0033700; P:phospholipid efflux; IMP:BHF-UCL
GO:0055091; P:phospholipid homeostasis; IMP:BHF-UCL
GO:0045542; P:positive regulation of cholesterol biosynthetic process; ISS:BHF-UCL
GO:0010875; P:positive regulation of cholesterol efflux; IEA:Ensembl
GO:0010872; P:regulation of cholesterol esterification; ISS:BHF-UCL
GO:0006355; P:regulation of transcription, DNA-templated; ISS:BHF-UCL
GO:0055099; P:response to high density lipoprotein particle; IEA:Ensembl
GO:0033993; P:response to lipid; IDA:BHF-UCL
GO:0010033; P:response to organic substance; IDA:UniProtKB
GO:0043691; P:reverse cholesterol transport; ISS:BHF-UCL
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:1901998; P:toxin transport; IDA:GOC
GO:0055085; P:transmembrane transport; TAS:Reactome
Interpro
InterPro; IPR003593; AAA+_ATPase
InterPro; IPR013525; ABC_2_trans
InterPro; IPR003439; ABC_transporter-like
InterPro; IPR017871; ABC_transporter_CS
InterPro; IPR020064; ABCG1
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005284; Pigment_permease
Pfam
Pfam; PF01061; ABC2_membrane;
Pfam; PF00005; ABC_tran;
SMART
SMART; SM00382; AAA;
PROSITE
PROSITE; PS00211; ABC_TRANSPORTER_1;
PROSITE; PS50893; ABC_TRANSPORTER_2;
PRINTS